{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:37:54Z","timestamp":1770838674647,"version":"3.50.1"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951118001920_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>A transannular patch is often used in the contemporary surgical repair of tetralogy of Fallot. This can lead to significant pulmonary insufficiency and increased right ventricular volumes and ultimately pulmonary valve replacement. Cardiopulmonary exercise testing is used to assess exercise capacity in tetralogy of Fallot patients before pulmonary valve replacement. There is only few published literatures on how lung function affects functional capacity in tetralogy of Fallot patients repaired with a transannular patch.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118001920_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was done from 2015 to 2017 on patients with tetralogy of Fallot who underwent maximal effort cardiopulmonary exercise testing with cycle ergometry and with concurrent pulmonary function testing. Tetralogy of Fallot patients repaired with a transannular patch without pulmonary valve replacement were compared with age, gender, and size-matched normal controls.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118001920_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In the tetralogy of Fallot group, 24 out of 57 patients underwent primary repair with a transannular patch. When compared to the normal controls, they demonstrated abnormal predicted forced expiratory volume in one second (79 \u00b1 23.1% versus 90.7 \u00b1 14.1%, p&lt;0.05), predicted maximal voluntary ventilation (74 \u00b1 18% versus 90.5 \u00b1 16.2%, p&lt;0.05) while having low-normal predicted forced vital capacity (80.5 \u00b1 17.2% versus 90.2 \u00b1 12.4%, p&lt;0.05) and normal breathing reserve percentage (50.3 \u00b1 11.3% versus 47.5 \u00b1 17.3%, p = 0.52). Cardiopulmonary exercise testing abnormalities included significantly lower percent predicted oxygen consumption (63.2 \u00b1 12.2% versus 87 \u00b1 12.1%, p&lt;0.05), maximal heart rate (171.8 \u00b1 18.9 versus 184.6 \u00b1 13.6, p&lt;0.05), and percent predicted maximum workload (61.7 \u00b1 15.9% versus 88.3 \u00b1 21.5%, p&lt;0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118001920_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Tetralogy of Fallot patients repaired with a transannular patch can have abnormal pulmonary function testing with poor exercise capacity in addition to chronotropic incompetence and impaired muscular power.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951118001920","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T05:23:31Z","timestamp":1543209811000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Pulmonary effects on exercise testing in tetralogy of Fallot patients repaired with a transannular patch"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-032X","authenticated-orcid":false,"given":"Adam W.","family":"Powell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne A.","family":"Mays","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra 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Pathophysiology and Clinical Applications","author":"Wasserman","year":"1999"},{"key":"S1047951118001920_ref12","volume-title":"Borg\u2019s Perceived Exertion and Pain Scales","author":"Borg","year":"1998"},{"key":"S1047951118001920_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-009-9544-9"},{"key":"S1047951118001920_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950160106"},{"key":"S1047951118001920_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900198"},{"key":"S1047951118001920_ref25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013588"},{"key":"S1047951118001920_ref27","first-page":"720","article-title":"Technical consideration related to the minute ventilation\/carbon dioxide output slope in patients with heart failure","volume":"124","author":"Ross","year":"2003","journal-title":"Exercise and the 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