{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:29:45Z","timestamp":1792114185928,"version":"4.4.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951118002238_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Although many clinical features that are not typically included in the diagnostic criteria for Kawasaki disease, such as gall bladder hydrops, are known to occur with Kawasaki disease, splenomegaly is not concerned. We investigated the relationship of splenomegaly with the development of coronary artery lesions in Kawasaki disease.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118002238_abs2\" sec-type=\"general\"><jats:title>Methods and results<\/jats:title><jats:p>This retrospective descriptive study was conducted through a review of medical records of children with Kawasaki disease from March 2011 to February 2017. We analysed information regarding clinical presentation, treatment, hospital stay, and outcome. A total of 396 patients during this 6-year period met the enrolment criteria. Of these, 77 (23.4%) underwent abdominal ultrasonography during the treatment period. The patients included 46 males and 31 females with an average age of 35.8 \u00b1 26.1 months. Gallbladder hydrops were detected in 32 patients, and acute acalculous cholecystitis was not found. Splenomegaly was detected in 21 patients. Kawasaki disease patients with gallbladder hydrops had no statistical difference in clinical or laboratory findings or in development of coronary artery lesions compared to patients without gallbladder hydrops. However, patients with splenomegaly belonged more to incomplete Kawasaki disease, had longer fever duration, had more frequent cervical lymphadenopathy and polymorphous rash, had higher neutrophil percentage, N-terminal fragment of pro-brain natriuretic peptide, and alanine aminotransferase levels, and a higher incidence of coronary artery lesions than patients without splenomegaly.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118002238_abs3\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Splenomegaly belongs to incomplete Kawasaki disease patients mainly with a higher incidence of coronary artery lesions than that of patients without it.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951118002238","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T06:34:16Z","timestamp":1545374056000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["Clinical aspects of splenomegaly as a possible predictive factor of coronary artery changes in Kawasaki disease"],"prefix":"10.1017","volume":"29","author":[{"given":"Dong Wan","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-2874","authenticated-orcid":false,"given":"Sung Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"S1047951118002238_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80600-0"},{"key":"S1047951118002238_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03567.x"},{"key":"S1047951118002238_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01377200"},{"key":"S1047951118002238_ref9","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.5.9574620"},{"key":"S1047951118002238_ref5","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/485758"},{"key":"S1047951118002238_ref4","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.144.4.7111740"},{"key":"S1047951118002238_ref16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1542\/peds.61.5.699","article-title":"Mucocutaneous lymph node syndrome: report of two cases complicated by gallbladder hydrops and diagnosed by ultrasound","volume":"61","author":"Magilavy","year":"1978","journal-title":"Pediatrics"},{"key":"S1047951118002238_ref19","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2016.150371"},{"key":"S1047951118002238_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000073061.55674.1b"},{"key":"S1047951118002238_ref18","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2010.526685"},{"key":"S1047951118002238_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.6.1379"},{"key":"S1047951118002238_ref1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1542\/peds.54.3.271","article-title":"A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan","volume":"54","author":"Kawasaki","year":"1974","journal-title":"Pediatrics"},{"key":"S1047951118002238_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000010"},{"key":"S1047951118002238_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-008-0900-3"},{"key":"S1047951118002238_ref10","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.157.1.2048509"},{"key":"S1047951118002238_ref7","doi-asserted-by":"publisher","DOI":"10.3109\/15513818509026899"},{"key":"S1047951118002238_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02821.x"},{"key":"S1047951118002238_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80600-0"},{"key":"S1047951118002238_ref14","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2011.41.7.394"},{"key":"S1047951118002238_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22098"},{"key":"S1047951118002238_ref2","first-page":"e927","article-title":"American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Council on Epidemiology and Prevention. Diagnosis, treatment, and long-term management of Kawasaki disease: A scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"S1047951118002238_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2009.06.007"},{"key":"S1047951118002238_ref13","doi-asserted-by":"publisher","DOI":"10.12980\/APJTB.4.2014C988"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951118002238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T22:33:49Z","timestamp":1662676429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951118002238\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1047951118002238"],"URL":"https:\/\/doi.org\/10.1017\/s1047951118002238","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,21]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2018\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}