{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:14:50Z","timestamp":1777421690478,"version":"3.51.4"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951118002500_abs1\" sec-type=\"general\"><jats:title>Aim<\/jats:title><jats:p>The aim was to attach importance to the hazards of ventricular pre-excitation on left ventricular systolic function and size.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118002500_abs2\" sec-type=\"general\"><jats:title>Method<\/jats:title><jats:p>We analysed the clinical, electrophysiological, and echocardiographic characteristics of the 25 cases with abnormal ventricular wall motion, left ventricular systolic dysfunction, or dilation with co-existing right-sided overt accessary pathways before and after ablation or medication during March 2011 and June 2017. Moreover, we compared the therapy effect between patients with ventricular pre-excitation-induced dilated cardiomyopathy and idiopathic dilated cardiomyopathy without ventricular pre-excitation.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118002500_abs3\" sec-type=\"general\"><jats:title>Result<\/jats:title><jats:p>Abnormal ventricular wall motion was demonstrated using M-mode echocardiography in 23 cases. The basal segments of the interventricular septum became thin and moved similarly to an aneurysm with typical bulging during end-systole, which was observed in 16 cases. Dilated cardiomyopathy was diagnosed in 14 cases. A total of 23 patients underwent successful ablations and received medications, and the other two patients received only oral medications because of young age. The prognosis of pre-excitation-induced dilated cardiomyopathy is better than idiopathic dilated cardiomyopathy. All the cases with abnormal ventricular wall motion demonstrated recovery of normal left ventricular ejection fraction and decreased left ventricular end-diastolic diameter through ablation.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118002500_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Ventricular pre-excitation caused by right-sided accessory pathways may result in abnormal ventricular wall motion, left ventricular systolic dysfunction, dilation, and even dilated cardiomyopathy. In some cases with dilated cardiomyopathy, ventricular pre-excitation may not be the cause of disease but a harmful factor which hampered the recovering of left ventricular systolic function. These conditions are indications for ablation with good prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951118002500","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T07:02:45Z","timestamp":1550214165000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Hazards of ventricular pre-excitation to left ventricular systolic function and ventricular wall motion in children: analysis of 25 cases"],"prefix":"10.1017","volume":"29","author":[{"given":"Baojing","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chencheng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiangqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-9381","authenticated-orcid":false,"given":"Ling","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"S1047951118002500_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01302-X"},{"key":"S1047951118002500_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup272"},{"key":"S1047951118002500_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01612.x"},{"key":"S1047951118002500_ref18","first-page":"248","article-title":"Dyssynchronous 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