{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:21Z","timestamp":1786999581702,"version":"build-2736575974"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"unspecified","delay-in-days":16,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"unspecified","delay-in-days":16,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951119000076_as1\">\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>(1) To characterise changes in dead space fraction during the first 120 post-operative hours in neonates undergoing stage 1 palliation for hypoplastic left heart syndrome, including hybrid procedure; (2) to document whether dead space fraction varied by shunt type (Blalock\u2013Taussig shunt and Sano) and hybrid procedure; and (3) to determine the association between dead space fraction and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951119000076_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective chart review in neonates undergoing stage 1 palliation for hypoplastic left heart syndrome in a cardiac intensive care unit over a consecutive 30-month period. A linear mixed model was used to determine the differences in dead space over time. Multivariable linear regression and a multivariable linear mixed model were used to assess the association between dead space and outcomes at different time points and over time, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951119000076_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty-four neonates received either a Blalock\u2013Taussig shunt (20.5%), Sano shunt (59%), or hybrid procedure (20.5%). Hospital mortality was 8.8%. Dead space fractions in patients undergoing the hybrid procedure were significantly lower on day 1 (p = 0.01) and day 2 (p = 0.02) and increased over time. A dead space fraction &gt;0.6 on post-operative days 3\u20135 was significantly associated with decreased duration of mechanical ventilation in all surgical groups (p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951119000076_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dead space fraction &gt;0.6 on post-operative days 3\u20135 was associated with lower duration of mechanical ventilation in all surgical groups. A more comprehensive, prospective assessment of dead space in this delicate patient population would likely be beneficial in improving outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951119000076","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T02:40:09Z","timestamp":1555468809000},"page":"481-487","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Dead space fractions in neonates following first-stage palliation for hypoplastic left heart syndrome"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-3285","authenticated-orcid":false,"given":"Pilar","family":"Anton-Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhucha","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounica","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu","family":"Pandurangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chasity","family":"Wellnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Nigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigham C.","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,4,17]]},"reference":[{"key":"S1047951119000076_ref6","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1460-9592.2006.01957.x","article-title":"Intraoperative and postoperative risk factors for prolonged mechanical ventilation after pediatric cardiac surgery","volume":"16","author":"Sz\u00e9kely","year":"2006","journal-title":"Paediatr Anaesth"},{"key":"S1047951119000076_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112002181"},{"key":"S1047951119000076_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001456"},{"key":"S1047951119000076_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev345"},{"key":"S1047951119000076_ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1555OC"},{"key":"S1047951119000076_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.022"},{"key":"S1047951119000076_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000226"},{"key":"S1047951119000076_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21009"},{"key":"S1047951119000076_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1042-7"},{"key":"S1047951119000076_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.04.003"},{"key":"S1047951119000076_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115001419"},{"key":"S1047951119000076_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107001461"},{"key":"S1047951119000076_ref4","first-page":"11","volume-title":"Respiratory Physiology - The Essentials","author":"West","year":"1995:"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951119000076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T19:38:25Z","timestamp":1721158705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951119000076\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1047951119000076"],"URL":"https:\/\/doi.org\/10.1017\/s1047951119000076","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2019\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}