{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T18:31:14Z","timestamp":1725388274271},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119000660_as1\"><jats:title>Background:<\/jats:title><jats:p>Little evidence exists to support pharmacotherapeutic strategies for heart failure management in paediatrics. A recent Europe-wide survey suggests that this translates into substantial variability in clinical practice.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000660_as2\"><jats:title>Objective:<\/jats:title><jats:p>To conduct a formal discussion among an expert group of paediatric cardiology physicians on controversial aspects regarding the pharmacotherapy of children heart failure, facilitate consensus, and highlight areas of agreement and disagreement.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000660_as3\" sec-type=\"methods\"><jats:title>Methods:<\/jats:title><jats:p>A two-round modified Delphi process was conducted between July and August 2015. Topics addressed were predominantly selected from the results of a previous Europe-wide survey. Fourteen statements were presented for discussion grouped under three categories; Angiotensin-converting-enzyme-inhibitors: Considerations for optimal dosage; Angiotensin-converting-enzyme-inhibitors for the management of CHDs; Neurohumoral antagonists for the management of dilated cardiomyopathy-related heart failure.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000660_as4\" sec-type=\"results\"><jats:title>Results:<\/jats:title><jats:p>A total of 13 paediatricians dedicated to cardiology from across Europe and the United States of America completed the study; of them, 92% had a working experience in the field of more than 10 years and were working in a specific paediatric cardiology unit. Agreement on the acceptance\/rejection of 11 statements was achieved. Results show agreement on the importance of a set of topics relevant to the standardisation of the therapy as well as consensus upon specific therapeutic attitudes.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000660_as5\" sec-type=\"conclusions\"><jats:title>Conclusions:<\/jats:title><jats:p>We have found areas of common thinking and motivation, which can provide a means of triggering scientific collaboration. Our results might also contribute to disseminate available paediatric evidence and promote reducing unjustified variability in everyday practice. Until solid evidence is available, other research methods can contribute to advancing the goal of safe and effective paediatric heart failure pharmacotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119000660","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T08:43:18Z","timestamp":1561365798000},"page":"869-876","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacotherapy in paediatric heart failure: a Delphi process"],"prefix":"10.1017","volume":"29","author":[{"given":"Cristina C.","family":"D\u00edez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feras","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Makowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schwender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Jovanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"Dalinghaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke","family":"van der Meulen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Bajcetic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia N.","family":"de Wildt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"L\u00e4er","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,6,24]]},"reference":[{"key":"S1047951119000660_ref26","first-page":"1","article-title":"The Delphi method for graduate research","volume":"6","author":"Skulmoski","year":"2007","journal-title":"JITE"},{"key":"S1047951119000660_ref35","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.115707"},{"key":"S1047951119000660_ref40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192518"},{"key":"S1047951119000660_ref13","first-page":"2011","volume-title":"The Delphi technique in nursing and health research","author":"Keeney"},{"key":"S1047951119000660_ref32","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-312774"},{"key":"S1047951119000660_ref47","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"S1047951119000660_ref33","first-page":"2016","volume-title":"Pediatric and Neonatal Dosage Handbook","author":"Taketomo"},{"key":"S1047951119000660_ref4","unstructured":"4. EMEA. Evidence of harm from off-label or unlicensed medicines in children. 2004. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Other\/2009\/10\/WC500004021.pdf"},{"key":"S1047951119000660_ref36","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114020"},{"key":"S1047951119000660_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00673-2"},{"key":"S1047951119000660_ref38","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.109389"},{"key":"S1047951119000660_ref29","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080372"},{"key":"S1047951119000660_ref50","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.ehj.2004.06.003","article-title":"Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease. The task force on ACE-inhibitors of the European Society of Cardiology","volume":"25","author":"L\u00f3pez-Send\u00f3n","year":"2004","journal-title":"Eur Heart J"},{"key":"S1047951119000660_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.12.002"},{"key":"S1047951119000660_ref20","first-page":"432.e1","article-title":"[Clinical consensus on respiratory syncytial virus (RSV) infection prophylaxis and the use of palivizumab in paediatric cardiology.]","volume":"72","author":"Medrano L\u00f3pez","year":"2010","journal-title":"An Pediatr Barc Spain 2003"},{"key":"S1047951119000660_ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0306-8"},{"key":"S1047951119000660_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003615"},{"key":"S1047951119000660_ref19","first-page":"1","article-title":"The Delphi technique: making sense of consensus","volume":"12","author":"Hsu","year":"2007","journal-title":"Pract Assess Res Eval"},{"key":"S1047951119000660_ref28","doi-asserted-by":"publisher","DOI":"10.4135\/9781526402202"},{"key":"S1047951119000660_ref22","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0263"},{"key":"S1047951119000660_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.099"},{"key":"S1047951119000660_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.08.008"},{"key":"S1047951119000660_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7001.376"},{"key":"S1047951119000660_ref37","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.820217"},{"key":"S1047951119000660_ref12","first-page":"543","article-title":"Potentially inappropriate medications in the elderly: the PRISCUS list","volume":"107","author":"Holt","year":"2010","journal-title":"Dtsch \u00c4rztebl Int"},{"key":"S1047951119000660_ref41","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-8-38"},{"key":"S1047951119000660_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70023-2"},{"key":"S1047951119000660_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7489(93)90033-Q"},{"key":"S1047951119000660_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.22.2716"},{"key":"S1047951119000660_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.im.2003.11.002"},{"key":"S1047951119000660_ref5","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb04021.x"},{"key":"S1047951119000660_ref11","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1046\/j.1365-2648.2000.t01-1-01567.x","article-title":"Research guidelines for the Delphi survey technique","volume":"32","author":"Hasson","year":"2000","journal-title":"J Adv Nurs"},{"key":"S1047951119000660_ref52","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-37"},{"key":"S1047951119000660_ref48","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829e8807"},{"key":"S1047951119000660_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.10.005"},{"key":"S1047951119000660_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0981-y"},{"key":"S1047951119000660_ref27","unstructured":"27. United Nations Secretariat, Statistics Division. Standard Country or area codes for statistical use (M49). Stand. Ctry. Area Codes Stat. Use M49. https:\/\/unstats.un.org\/unsd\/methodology\/m49 (accessed 20 Apr 2018)."},{"key":"S1047951119000660_ref25","unstructured":"25. Delbecq, A , Ven, A , Gustafson, D . Group techniques for program planning: A guide to nominal groups and Delphi processes. Gustafson Glenview, III.: Scott, Foresman, 1975."},{"key":"S1047951119000660_ref42","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111600295X"},{"key":"S1047951119000660_ref24","first-page":"265","article-title":"The use of a modified Delphi procedure for the determination of 26 prognostic factors in the sub-acute stage of stroke","volume":"26","author":"Meijer","year":"2003","journal-title":"Int J Rehabil Res Int Z Rehabil Rev Int Rech Readaptation"},{"key":"S1047951119000660_ref23","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-3014"},{"key":"S1047951119000660_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-5915.1997.tb01330.x"},{"key":"S1047951119000660_ref51","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.15.1867"},{"key":"S1047951119000660_ref49","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007037.pub3"},{"key":"S1047951119000660_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.10.030"},{"key":"S1047951119000660_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70273-X"},{"key":"S1047951119000660_ref17","first-page":"2014","volume-title":"Delphi-befragungen: Ein Arbeitsbuch","author":"H\u00e4der"},{"key":"S1047951119000660_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-52"},{"key":"S1047951119000660_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-3287(69)80025-X"},{"key":"S1047951119000660_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.002"},{"key":"S1047951119000660_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.927988"},{"key":"S1047951119000660_ref30","doi-asserted-by":"publisher","DOI":"10.1027\/1614-2241.4.2.73"},{"key":"S1047951119000660_ref16","unstructured":"16. Dalkey, , Helmer-Hirschberg, O . An Experimental Application of the Delphi Method to the Use of Experts. Published Online First: 1962. Retrieved April 19, 2018, from https:\/\/www.rand.org\/pubs\/research_memoranda\/RM727z1.html"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951119000660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T04:28:59Z","timestamp":1721449739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951119000660\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,24]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1047951119000660"],"URL":"https:\/\/doi.org\/10.1017\/s1047951119000660","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,24]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2019\u00a0","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}