{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:02:26Z","timestamp":1785160946830,"version":"3.55.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119000799_as1\"><jats:title>Background:<\/jats:title><jats:p>Challenges remain in the judgement of pathological murmurs in newborns at maternity hospitals, and there are still many simple major CHD patients in developing countries who are not diagnosed in a timely fashion. This study aimed to evaluate the accuracy of cardiac auscultation on neonatal CHD by general paediatricians.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000799_as2\"><jats:title>Methods:<\/jats:title><jats:p>We conducted a prospective study at three hospitals. All asymptomatic newborns underwent auscultation, pulse oximetry monitoring, and echocardiography. Major CHD was classified and confirmed through follow-up. We evaluated the accuracy of various degrees of murmurs for detecting major CHD to determine the most appropriate standards and time of auscultation.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000799_as3\"><jats:title>Results:<\/jats:title><jats:p>A total of 6750 newborns were included. The median age of auscultation was 43 hours. Cardiac murmurs were identified in 6.6% of newborns. For all CHD, 44.4% had varying degrees of murmurs. A murmur of grade \u22652 used as a reference standard for major CHD had a sensitivity of 89.58%. The false positive rate of murmurs of grade \u22652 for detecting major CHD was significantly negatively related to auscultation time, with 84.4% of false positives requiring follow-up for non-major CHD cardiac issues. Auscultation after 27 hours of life could reduce the false positive rate of major CHD from 2.7 to 0.9%.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000799_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>With appropriate training, maternity hospital\u2019s paediatricians can detect major CHD with high detection rates with an acceptable false positive rate.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119000799","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T09:15:24Z","timestamp":1556010924000},"page":"679-683","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Accuracy of cardiac auscultation in detection of neonatal congenital heart disease by general paediatricians"],"prefix":"10.1017","volume":"29","author":[{"given":"Qu-ming","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conway","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-4646","authenticated-orcid":false,"given":"Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"S1047951119000799_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.06.017"},{"key":"S1047951119000799_ref23","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1377"},{"key":"S1047951119000799_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60278-0"},{"key":"S1047951119000799_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951117002591"},{"key":"S1047951119000799_ref11","doi-asserted-by":"publisher","DOI":"10.1586\/erc.09.141"},{"key":"S1047951119000799_ref7","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2017-0084"},{"key":"S1047951119000799_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-1122-1"},{"key":"S1047951119000799_ref8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1051\/ject\/201749098","article-title":"Cardiac 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of cardiac auscultation in asymptomatic neonates with heart murmurs: comparison between pediatric trainees and neonatologists","volume":"32","author":"Karatza","year":"2011","journal-title":"Pediatr Cardiol"},{"key":"S1047951119000799_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02687.x"},{"key":"S1047951119000799_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60753-8"},{"key":"S1047951119000799_ref15","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903009230"},{"key":"S1047951119000799_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-011-9991-y"}],"container-title":["Cardiology in the 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