{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:33:03Z","timestamp":1773282783324,"version":"3.50.1"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119000829_as1\"><jats:title>Introduction:<\/jats:title><jats:p>Reliable predictors of extubation readiness are needed and may reduce morbidity related to extubation failure. We aimed to examine the relationship between changes in pre-extubation near-infrared spectroscopy measurements from baseline and extubation outcomes after neonatal cardiac surgery.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000829_as2\"><jats:title>Materials and Methods:<\/jats:title><jats:p>In this retrospective cross-sectional multi-centre study, a secondary analysis of prospectively collected data from neonates who underwent cardiac surgery at seven tertiary-care children\u2019s hospitals in 2015 was performed. Extubation failure was defined as need for re-intubation within 72 hours of the first planned extubation attempt. Near-infrared spectroscopy measurements obtained before surgery and before extubation in patients who failed extubation were compared to those of patients who extubated successfully using t-tests.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000829_as3\"><jats:title>Results:<\/jats:title><jats:p>Near-infrared spectroscopy measurements were available for 159 neonates, including 52 with single ventricle physiology. Median age at surgery was 6 days (range: 1\u201329 days). A total of 15 patients (9.4 %) failed extubation. Baseline cerebral and renal near-infrared spectroscopy measurements were not statistically different between those who were successfully extubated and those who failed, but pre-extubation cerebral and renal values were significantly higher in neonates who extubated successfully. An increase from baseline to time of extubation values in cerebral oximetry saturation by \u2265 5 % had a positive predictive value for extubation success of 98.6 % (95%CI: 91.1\u201399.8 %).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000829_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Pre-extubation cerebral near-infrared spectroscopy measurements, when compared to baseline, were significantly associated with extubation outcomes. These findings demonstrate the potential of this tool as a valuable adjunct in assessing extubation readiness after paediatric cardiac surgery and warrant further evaluation in a larger prospective study.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119000829","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T10:18:20Z","timestamp":1559816300000},"page":"787-792","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Near-infrared spectroscopy for prediction of extubation success after neonatal cardiac surgery"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2167-363X","authenticated-orcid":false,"given":"Eleanor A.","family":"Gradidge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Cashen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshava M. N.","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt D.","family":"Piggott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Costello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher W.","family":"Mastropietro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"S1047951119000829_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000780"},{"key":"S1047951119000829_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000094228.90557.85"},{"key":"S1047951119000829_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181e8b430"},{"key":"S1047951119000829_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000161119.05076.91"},{"key":"S1047951119000829_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2618-0"},{"key":"S1047951119000829_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318193724d"},{"key":"S1047951119000829_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.01.071"},{"key":"S1047951119000829_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200204000-00011"},{"key":"S1047951119000829_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31819a7f60"},{"key":"S1047951119000829_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.09.100"},{"key":"S1047951119000829_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182389531"},{"key":"S1047951119000829_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.12.028"},{"key":"S1047951119000829_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31828a8964"},{"key":"S1047951119000829_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.12.042"},{"key":"S1047951119000829_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-0906-7"},{"key":"S1047951119000829_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112002181"},{"key":"S1047951119000829_ref16","first-page":"885066617741435","article-title":"Decreases in mixed venous blood O2 saturations in cardiac surgery patients following extubation","volume":"1","author":"Williams","year":"2017","journal-title":"J Intensive Care Med"},{"key":"S1047951119000829_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000498"},{"key":"S1047951119000829_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000512"},{"key":"S1047951119000829_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199401000-00016"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951119000829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T10:36:27Z","timestamp":1617705387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951119000829\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S1047951119000829"],"URL":"https:\/\/doi.org\/10.1017\/s1047951119000829","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2019\u00a0","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}