{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:49:37Z","timestamp":1773085777622,"version":"3.50.1"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119000842_as1\"><jats:title>Background:<\/jats:title><jats:p>Tricuspid valve regurgitation is an inherent part of Ebstein\u2019s anomaly, yet whether the severity of the regurgitation further impairs exercise capacity and contributes to long-term morbidity on top of the lesion severity per se is unknown.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000842_as2\"><jats:title>Methods:<\/jats:title><jats:p>To evaluate for this potential effect, we included 30 patients with Ebstein\u2019s anomaly who did not undergo any form of surgical interventions and had a cardiopulmonary exercise test and echocardiographic studies in this retrospective analysis. Echocardiographic studies and cardiopulmonary exercise tests were critically reviewed for lesion severity grade, tricuspid regurgitation degree, and exercise parameters. Cardiac-related hospitalisations were recorded from computerised medical records and during clinic visits.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000842_as3\"><jats:title>Results:<\/jats:title><jats:p>Fourteen patients (47%) had moderate and 8 (27%) had severe regurgitation. Patients with \u2265 moderate regurgitation exhibited significantly lower exercise capacity (median % predicted maximal oxygen consumption, 62 versus 79%, p = 0.03) and venilatory efficiency at exercise. When stratifying exercise results by regurgitation degree, a stepwise decrease in oxygen consumption and ventilatory efficiency with increasing regurgitation severity was observed, regardless of the anatomic lesion severity. During a median follow-up of 4.6 years, &gt; moderate tricuspid regurgitation was associated with significantly lower cumulative probability of freedom from cardiac hospitalisations.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119000842_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>We report that among non-operated Ebstein\u2019s anomaly patients, greater tricuspid regurgitation severity was associated with worse exercise capacity and with overall higher probability of cardiac-related hospitalisations independent from the underlying lesion severity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119000842","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T08:47:27Z","timestamp":1559638047000},"page":"800-807","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["The impact of tricuspid valve regurgitation severity on exercise capacity and cardiac-related hospitalisations among adults with non-operated Ebstein\u2019s anomaly"],"prefix":"10.1017","volume":"29","author":[{"given":"Jonathan","family":"Buber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Vatury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Klempfner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shai","family":"Tejman-Yarden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"S1047951119000842_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70088-7"},{"key":"S1047951119000842_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000406"},{"key":"S1047951119000842_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.08.004"},{"key":"S1047951119000842_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.12.006"},{"key":"S1047951119000842_ref14","first-page":"e521","article-title":"AHA\/ACC 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disease)","volume":"118","author":"Warnes","year":"2008","journal-title":"Circulation"},{"key":"S1047951119000842_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.07.019"},{"key":"S1047951119000842_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90516-9"},{"key":"S1047951119000842_ref3","first-page":"238","article-title":"Ueber einen sehr seltenen Fall von Insufficienz der Valvula tricuspidalis, bedinct drch eine angeborene hochgradige Missbildung derselben","author":"Ebstein","year":"1866","journal-title":"Arch Anat Physiol"}],"container-title":["Cardiology in the 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