{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:27:50Z","timestamp":1773815270664,"version":"3.50.1"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119001112_as1\"><jats:title>Background:<\/jats:title><jats:p>Significant inter-centre variability in the intensity of endomyocardial biopsy surveillance for rejection following paediatric cardiac transplantation has been reported. Our aim was to determine if low-intensity biopsy surveillance with two scheduled biopsies in the first year would produce outcomes similar to published registry outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001112_as2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective study of paediatric recipients transplanted between 2008 and 2014 using a low-intensity biopsy protocol consisting of two surveillance biopsies at 3 and 12\u201313 months in the first post-transplant year, then annually thereafter. Additional biopsies were performed based on echocardiographic and clinical surveillance. Excluded were recipients that were re-transplanted or multi-organ transplanted or were followed at another institution.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001112_as3\"><jats:title>Results:<\/jats:title><jats:p>A total of 81 recipients in the first 13 months after transplant underwent an average of 2 (SD \u00b1 1.3) biopsies, 24 \u00b1 6.8 echocardiograms, and 17 \u00b1 4.4 clinic visits per recipient. During the 13-month period, 19 recipients had 24 treated rejection episodes, with the first at an average of 2.8 months post-transplant. The 3-, 12-, 36-, and 60-month conditional on discharge graft survival were 100%, 98.8%, 98.8%, and 90.4%, respectively, comparable to reported figures in major paediatric registries. At a mean follow-up of 4.7 \u00b1 2.1 years, four patients (4.9%) developed cardiac allograft vasculopathy, three (3.7%) developed a malignancy, and seven (8.6%) suffered graft loss.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001112_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Rejection surveillance with a low-intensity biopsy protocol demonstrated similar intermediate-term outcomes and safety measures as international registries up to 5 years post-transplant.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119001112","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T10:13:38Z","timestamp":1560766418000},"page":"910-916","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Outcomes of low-intensity biopsy surveillance for rejection in paediatric cardiac transplantation"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-1926","authenticated-orcid":false,"given":"Patrick D.","family":"Evers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borah","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Albers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariska","family":"Kemna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Friedland-Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Boucek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuk","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"S1047951119001112_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.04.114"},{"key":"S1047951119001112_ref3","first-page":"813","article-title":"Heart transplant rejection with hemodynamic compromise: a multiinstitutional study of the role of endomyocardial cellular infiltrate. 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