{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:13:07Z","timestamp":1780441987997,"version":"3.54.1"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119001598_as1\"><jats:title>Background:<\/jats:title><jats:p>There are limited outcome data in adults with tetralogy of Fallot and pulmonary atresia. The purpose of this study was to describe re-operations and all-cause mortality in adults with tetralogy of Fallot and pulmonary atresia.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001598_as2\"><jats:title>Methods:<\/jats:title><jats:p>Retrospective review of adults with repaired tetralogy of Fallot and pulmonary atresia who received care at the Mayo Adult Congenital Heart Disease Clinic, 1990\u20132016. All-cause mortality was calculated as events per 100 patient-years from the time of first presentation to the Adult Congenital Heart Disease Clinic.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001598_as3\"><jats:title>Results:<\/jats:title><jats:p>Of the 221 patients, the age at initial tetralogy of Fallot repair was 6 (5\u201313) years, and the age at first presentation to the clinic was 27 \u2013 8 years. All patients had at least one right ventricular to pulmonary artery conduit re-operation. There were 31 deaths (14%) at mean age of 41 \u2013 14\u00a0years. The causes of death were end-stage heart failure (n = 17), sudden cardiac death (n=9), post-operative death after cardiac surgery (n = 2), sepsis with multi-system organ failure (n = 2), and unknown (n = 1). All-cause mortality rate was 1.7 per 100 patient-years. The risk factors for all-cause mortality were older age (&gt;12 years) at the time of repair (hazard ratio 1.41, 95 confidence interval 1.06\u20132.02, p = 0.033), non-sustained ventricular tachycardia (hazard ratio 1.36, 95 confidence interval 1.17\u20132.47, p = 0.015), and left ventricular ejection fraction &lt;50% (hazard ratio 1.39, 95 confidence interval 1.08\u20132.31, p = 0.031).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001598_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Based on a review of 221 adults with repaired tetralogy of Fallot and pulmonary atresia, all patients had re-operations and all-cause mortality rate was 1.7 events per 100 patient-years. The current study provides important outcomes data for risk stratification in adults with tetralogy of Fallot and pulmonary atresia.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119001598","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T03:28:05Z","timestamp":1562729285000},"page":"1078-1081","source":"Crossref","is-referenced-by-count":7,"title":["Long-term outcomes in adults with repaired tetralogy of Fallot and pulmonary atresia"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-3631","authenticated-orcid":false,"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Crestanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Dearani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthana","family":"Banala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounika","family":"Angirekula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Najam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naser M.","family":"Ammash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"S1047951119001598_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.726372"},{"key":"S1047951119001598_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy017"},{"key":"S1047951119001598_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.02.029"},{"key":"S1047951119001598_ref15","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312048"},{"key":"S1047951119001598_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.15.1826"},{"key":"S1047951119001598_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.03.110"},{"key":"S1047951119001598_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.03.061"},{"key":"S1047951119001598_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0921-7"},{"key":"S1047951119001598_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.032"},{"key":"S1047951119001598_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310068"},{"key":"S1047951119001598_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.10.115"},{"key":"S1047951119001598_ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2009.01.017"},{"key":"S1047951119001598_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"S1047951119001598_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0884-8"},{"key":"S1047951119001598_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.12.066"},{"key":"S1047951119001598_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.928481"},{"key":"S1047951119001598_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304958"},{"key":"S1047951119001598_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv550"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951119001598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T09:20:39Z","timestamp":1566897639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951119001598\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,10]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1047951119001598"],"URL":"https:\/\/doi.org\/10.1017\/s1047951119001598","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,10]]}}}