{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:41:16Z","timestamp":1778186476930,"version":"3.51.4"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119001859_as1\"><jats:title>Background:<\/jats:title><jats:p>While echocardiographic parameters are used to quantify ventricular function in infants with single ventricle physiology, there are few data comparing these to invasive measurements. This study correlates echocardiographic measures of diastolic function with ventricular end-diastolic pressure in infants with single ventricle physiology prior to superior cavopulmonary anastomosis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001859_as2\"><jats:title>Methods:<\/jats:title><jats:p>Data from 173 patients enrolled in the Pediatric Heart Network Infant Single Ventricle enalapril trial were analysed. Those with mixed ventricular types (n = 17) and one outlier (end-diastolic pressure = 32 mmHg) were excluded from the analysis, leaving a total sample size of 155 patients. Echocardiographic measurements were correlated to end-diastolic pressure using Spearman\u2019s test.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001859_as3\"><jats:title>Results:<\/jats:title><jats:p>Median age at echocardiogram was 4.6 (range 2.5\u20137.4) months. Median ventricular end-diastolic pressure was 7 (range 3\u201319) mmHg. Median time difference between the echocardiogram and catheterisation was 0 days (range \u221235 to 59 days). Examining the entire cohort of 155 patients, no echocardiographic diastolic function variable correlated with ventricular end-diastolic pressure. When the analysis was limited to the 86 patients who had similar sedation for both studies, the systolic:diastolic duration ratio had a significant but weak negative correlation with end-diastolic pressure (r = \u22120.3, p = 0.004). The remaining echocardiographic variables did not correlate with ventricular end-diastolic pressure.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001859_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>In this cohort of infants with single ventricle physiology prior to superior cavopulmonary anastomosis, most conventional echocardiographic measures of diastolic function did not correlate with ventricular end-diastolic pressure at cardiac catheterisation. These limitations should be factored into the interpretation of quantitative echo data in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119001859","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T07:36:22Z","timestamp":1567496182000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-9565","authenticated-orcid":false,"given":"Suma P.","family":"Goudar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-3194","authenticated-orcid":false,"given":"Victor","family":"Zak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Atz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Altmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Colan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine B.","family":"Falkensammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark K.","family":"Friedberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Frommelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin D.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne T.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jami C.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Margossian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Mart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Sticka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Shrader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Shirali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Pediatric Heart Network Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"S1047951119001859_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.08.002"},{"key":"S1047951119001859_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0888-4"},{"key":"S1047951119001859_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.03.058"},{"key":"S1047951119001859_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00511-X"},{"key":"S1047951119001859_ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.001071"},{"key":"S1047951119001859_ref9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0025-6196(11)64884-2","article-title":"Diastolic ventricular function in children: a Doppler echocardiographic study establishing normal values and predictors of increased ventricular end-diastolic pressure","volume":"73","author":"O\u2019Leary","year":"1998","journal-title":"Mayo Clin Proc"},{"key":"S1047951119001859_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.05.034"},{"key":"S1047951119001859_ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2001.113542"},{"key":"S1047951119001859_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.08.011"},{"key":"S1047951119001859_ref29","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181e5d543"},{"key":"S1047951119001859_ref18","first-page":"135","article-title":"New non-invasive index for combined systolic and diastolic ventricular function","volume":"26","author":"Tei","year":"1995","journal-title":"J Cardiol"},{"key":"S1047951119001859_ref4","first-page":"987","article-title":"Pulmonary transvalvular and venous flows in the estimation of left ventricular diastolic pressures. 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