{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:19:31Z","timestamp":1773685171185,"version":"3.50.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119001872_as1\" sec-type=\"other\"><jats:title>Objective:<\/jats:title><jats:p>Left ventricular non-compaction is an architectural abnormality of the myocardium, associated with heart failure, systemic thromboembolism, and arrhythmia. We sought to assess the prevalence of left ventricular non-compaction in patients with single ventricle heart disease and its effects on ventricular function.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001872_as2\" sec-type=\"other\"><jats:title>Methods:<\/jats:title><jats:p>Cardiac MRI of 93 patients with single ventricle heart disease (mean age 24 \u00b1 8 years; 55% male) from three tertiary congenital centres was retrospectively reviewed; 65 of these had left ventricular morphology and are the subject of this report. The presence of left ventricular non-compaction was defined as having a non-compacted:compacted (NC:C) myocardial thickness ratio &gt;2.3:1. The distribution of left ventricular non-compaction, ventricular volumes, and function was correlated with clinical data.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001872_as3\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>The prevalence of left ventricular non-compaction was 37% (24 of 65 patients) with a mean of 4 \u00b1 2 affected segments. The distribution was apical in 100%, mid-ventricular in 29%, and basal in 17% of patients. Patients with left ventricular non-compaction had significantly higher end-diastolic (128 \u00b1 44 versus 104 \u00b1 46 mL\/m<jats:sup>2<\/jats:sup>, p = 0.047) and end-systolic left ventricular volumes (74 \u00b1 35 versus 56 \u00b1 35 mL\/m<jats:sup>2<\/jats:sup>, p = 0.039) with lower left ventricular ejection fraction (44 \u00b1 11 versus 50 \u00b1 9%, p = 0.039) compared to those with normal compaction. The number of segments involved did not correlate with ventricular function (p = 0.71).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119001872_as4\" sec-type=\"other\"><jats:title>Conclusions:<\/jats:title><jats:p>Left ventricular non-compaction is frequently observed in patients with left ventricle-type univentricular hearts, with predominantly apical and mid-ventricular involvement. The presence of non-compaction is associated with increased indexed end-diastolic volumes and impaired systolic function.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119001872","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T05:57:02Z","timestamp":1578549422000},"page":"12-18","source":"Crossref","is-referenced-by-count":3,"title":["Left ventricular non-compaction in patients with single ventricle heart disease"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-167X","authenticated-orcid":false,"given":"Preeti","family":"Choudhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Strugnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Puranik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hamilton-Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-0979","authenticated-orcid":false,"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S","family":"Celermajer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"S1047951119001872_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.02.056"},{"key":"S1047951119001872_ref10","first-page":"207","article-title":"LV noncompaction in Ebstein\u2019s anomaly in infants and outcomes","volume":"7","author":"Pignatelli","year":"2014","journal-title":"JACC: Cardiovasc Imaging"},{"key":"S1047951119001872_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951106001351"},{"key":"S1047951119001872_ref17","first-page":"931","article-title":"Comparison of systolic and diastolic criteria for isolated LV noncompaction in cardiac MRI","volume":"6","author":"Stacey","year":"2013","journal-title":"JACC: Cardiovasc 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Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951119001872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T08:57:15Z","timestamp":1579769835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951119001872\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1047951119001872"],"URL":"https:\/\/doi.org\/10.1017\/s1047951119001872","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}