{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:55:58Z","timestamp":1761562558367,"version":"3.40.5"},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S104795111900194X_as1\"><jats:title>Background:<\/jats:title><jats:p>The Fontan procedure is the final stage of surgical palliation for a single-ventricle circulation. Significant complications are common including rhythm disturbance necessitating implantation of a permanent pacemaker. This has been widely considered a negative prognostic indicator.<\/jats:p><\/jats:sec><jats:sec id=\"S104795111900194X_as2\"><jats:title>Methods:<\/jats:title><jats:p>This single-centre, retrospective case control study involved all patients who underwent the Fontan procedure at the Leeds Congenital Heart Unit between 1990 and 2015 and have had regular follow-up in Yorkshire and Humber, United Kingdom. 167 Fontan patients were identified of which 2 were excluded for having a pre-procedure pacemaker. Of the remainder, 23 patients required a pacemaker. Outcomes were survival, early and late complications, need for further intervention and oxygen saturation in long-term follow-up.<\/jats:p><\/jats:sec><jats:sec id=\"S104795111900194X_as3\"><jats:title>Results:<\/jats:title><jats:p>There was no difference in survival (30-day survival pacemaker 92.6%, sinus rhythm 90.5%, p = 0.66, 1-year pacemaker 11.1%, sinus rhythm 10.1%, p = 1). The pacemaker group was more likely to have cerebral or renal complications in the first-year post-procedure (acute kidney injury: sinus rhythm 0.8%, pacemaker 19.1%, p = 0.002). No difference was observed in longer term complications including protein losing enteropathy (sinus rhythm 3.5%, pacemaker 0% p = 1). There was no difference in saturations between the two groups at follow-up. Paced patients were more likely to have required further intervention, with a higher incidence of cardiopulmonary bypass procedures (sinus rhythm 6.3%, pacemaker 35%, p &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S104795111900194X_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Despite an increase in early complications and the need for further interventions, pacemaker requirement does not appear to affect long-term survival following the Fontan procedure.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s104795111900194x","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T04:55:59Z","timestamp":1570769759000},"page":"1432-1434","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Permanent pacing post-Fontan is not associated with reduced long-term survival"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7403-0785","authenticated-orcid":false,"given":"Sally J.","family":"Hall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Cullington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D. R.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Bentham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"S104795111900194X_ref1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.068684"},{"key":"S104795111900194X_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00251-2"},{"key":"S104795111900194X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.025"},{"key":"S104795111900194X_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.065"},{"key":"S104795111900194X_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx022"},{"key":"S104795111900194X_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-198904000-00018"},{"key":"S104795111900194X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.074"},{"key":"S104795111900194X_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.26.3.240"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795111900194X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T09:24:46Z","timestamp":1577697886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795111900194X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S104795111900194X"],"URL":"https:\/\/doi.org\/10.1017\/s104795111900194x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2019,10,11]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2019\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}