{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:59:04Z","timestamp":1747173544186,"version":"3.40.5"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951119002919_as1\" sec-type=\"other\"><jats:title>Introduction:<\/jats:title><jats:p>Secundum atrial septal defect is one of the most common congenital heart defects. Previous paediatric studies have mainly addressed echocardiographic and few clinical factors among children associated with adverse events. The aim of this study was to identify neonatal and other clinical risk factors associated with adverse events up to one year after closure of atrial septal defect.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119002919_as2\" sec-type=\"other\"><jats:title>Methods:<\/jats:title><jats:p>This retrospective case\u2013control study includes children born in Sweden between 2000 and 2014 that were treated surgically or percutaneously for an atrial septal defect. Conditional logistic regression was used to evaluate the association between major and minor adverse events and potential risk factors, adjusting for confounding factors including prematurity, neonatal sepsis, neonatal general ventilatory support, symptomatic atrial septal defects, and pulmonary hypertension.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119002919_as3\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>Overall, 396 children with 400 atrial septal defect closures were included. The median body weight at closure was 14.5 (3.5\u2013110) kg, and the median age was 3.0 (0.1\u201317.8) years. Overall, 110 minor adverse events and 68 major events were recorded in 87 and 49 children, respectively. Only symptomatic atrial septal defects were associated with both minor (odds ratio (OR) = 2.18, confidence interval (CI) 95% 1.05\u20138.06) and major (OR = 2.80 CI 95% 1.23\u20136.37) adverse events.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951119002919_as4\" sec-type=\"other\"><jats:title>Conclusion:<\/jats:title><jats:p>There was no association between the investigated neonatal comorbidities and major or minor events after atrial septal defect closure. Patients with symptomatic atrial septal defects had a two to four times increased risk of having a major event, suggesting careful management and follow-up of these children prior to and after closure.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951119002919","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T04:41:37Z","timestamp":1576644097000},"page":"303-312","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors for adverse events within one year after atrial septal closure in children: a retrospective follow-up study"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-3318","authenticated-orcid":false,"given":"Gustaf","family":"Tangh\u00f6j","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petru","family":"Liuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Sj\u00f6berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estelle","family":"Naumburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"S1047951119002919_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.01.001"},{"key":"S1047951119002919_ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1787-2"},{"key":"S1047951119002919_ref37","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"S1047951119002919_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.126920"},{"key":"S1047951119002919_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2011.00540.x"},{"key":"S1047951119002919_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01862-4"},{"key":"S1047951119002919_ref40","unstructured":"40. Ulf Thil\u00e9n, GB , Jeremiasen, I , Bj\u00f6rkhem, G , Bergman, G. Nationellt register f\u00f6r medf\u00f6dda hj\u00e4rtsjukdomar, 2017. http:\/\/www.ucr.uu.se\/swedcon\/."},{"key":"S1047951119002919_ref36","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2006.02.005"},{"key":"S1047951119002919_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00765.x"},{"key":"S1047951119002919_ref33","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104002069"},{"key":"S1047951119002919_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.02.051"},{"key":"S1047951119002919_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2021"},{"key":"S1047951119002919_ref39","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2014.003"},{"key":"S1047951119002919_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111100093X"},{"key":"S1047951119002919_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26300"},{"key":"S1047951119002919_ref35","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304225"},{"key":"S1047951119002919_ref5","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1093\/eurheartj\/ehq249","article-title":"ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)","volume":"31","author":"Baumgartner","year":"2010","journal-title":"Eur Heart J"},{"key":"S1047951119002919_ref7","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.062554"},{"key":"S1047951119002919_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31821b1f10"},{"key":"S1047951119002919_ref19","unstructured":"19. 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