{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:59:13Z","timestamp":1747173553517,"version":"3.40.5"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S104795112000058X_as1\" sec-type=\"other\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the diagnostic and predictive values of plasma connective tissue growth factor in children with pulmonary hypertension (PH)-related CHD.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112000058X_as2\" sec-type=\"other\"><jats:title>Patients and methods:<\/jats:title><jats:p>Forty patients with PH-related CHD were enrolled as group I, and 40 patients with CHD and no PH served as group II. Forty healthy children of matched age and sex served as a control group. Echocardiographic examinations and plasma connective tissue growth factor levels were performed for all included children. Cardiac catheterisation was performed for children with CHD only.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112000058X_as3\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>Plasma connective tissue growth factor levels were significantly higher in children with PH-related CHD compared to CHD-only patients and to control group and this elevation went with the severity of PH. There was a significant positive correlation between connective tissue growth factor levels and mean pulmonary pressure, pulmonary vascular resistance, and right ventricular diameter. A significant negative correlation was noticed between connective tissue growth factor levels, oxygen saturation, and right ventricular diastolic function. The sensitivity of plasma connective tissue growth factor as a diagnostic biomarker for PH was 95%, and the specificity was 90% at a cut-off value \u2265650 pg\/mL. The predictive value of plasma connective tissue growth factor for adverse outcome had a sensitivity of 88% and a specificity of 83% at a cut-off value \u22651900 pg\/mL.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112000058X_as4\" sec-type=\"other\"><jats:title>Conclusion:<\/jats:title><jats:p>Connective tissue growth factor is a promising biomarker with good diagnostic and predictive values in children with PH-related CHD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s104795112000058x","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T05:48:35Z","timestamp":1585633715000},"page":"533-538","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic and predictive values of plasma connective tissue growth factor in children with pulmonary hypertension associated with CHD"],"prefix":"10.1017","volume":"30","author":[{"given":"Eslam","family":"Hella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-1170","authenticated-orcid":false,"given":"Doaa","family":"El Amrousy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"El-Serogy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Zoair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"S104795112000058X_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.01.023"},{"key":"S104795112000058X_ref18","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00006511"},{"key":"S104795112000058X_ref17","first-page":"359","article-title":"Expression of connective tissue growth factor and its down-regulation by simvastatin administration in pulmonary hypertensive rats","volume":"46","author":"Liu","year":"2008","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"S104795112000058X_ref16","first-page":"1013","article-title":"Changes of TGF-b1 and CTGF in rats with increased blood flow-induced pulmonary artery hypertension","volume":"37","author":"Zhu","year":"2014","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue 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Er Ke Za Zhi"},{"key":"S104795112000058X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.07.025"},{"key":"S104795112000058X_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115002255"},{"key":"S104795112000058X_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1335-x"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795112000058X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T13:10:45Z","timestamp":1587733845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795112000058X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S104795112000058X"],"URL":"https:\/\/doi.org\/10.1017\/s104795112000058x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2020,3,31]]}}}