{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:37:06Z","timestamp":1790948226565,"version":"4.1.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S104795112000089X_as1\" sec-type=\"other\"><jats:title>Objective:<\/jats:title><jats:p>The aim of this study was to investigate the relationship between C-reactive protein and erythrocyte sedimentation rate and neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios in acute rheumatic fever in children.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112000089X_as2\" sec-type=\"other\"><jats:title>Method:<\/jats:title><jats:p>In this retrospective study, 182 patients with acute rheumatic fever and 173 controls were included. Complete blood count parameters, and neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were recorded for all the patients underwent transthoracic echocardiography.<\/jats:p><\/jats:sec><jats:sec id=\"S104795112000089X_as3\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were significantly higher in patients with rheumatic heart disease than patients without cardiac involvement (p &lt; 0.05). C-reactive protein and erythrocyte sedimentation rate levels were found to have a positive correlation with neutrophil-to-lymphocyte (r = 0.228, p = 0.001; r = 0.355, p = 0.001), platelet-to-lymphocyte (r = 0.227, p = 0.01; r = 0.149, p = 0.005), and monocyte-to-lymphocyte ratios (r = 0.117, p = 0.005; r = 0.107, p = 0.044). Cardiac involvement was present in 152 (83.5%) of the patients. Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were significantly higher in patients with rheumatic heart disease than patients without cardiac involvement (p &lt; 0.05). Patients with carditis were grouped according to mitral, aortic, or both valve involvement but there was no significant difference between the groups with respect to neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios. In addition, neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios were significantly higher in patients with Sydenham\u2019s chorea than without chorea (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S104795112000089X_as4\" sec-type=\"other\"><jats:title>Conclusion:<\/jats:title><jats:p>Neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios may help make the diagnosis of acute rheumatic fever and its prognosis by serial measurements in follow-up but none of them tell us the severity of carditis. Also, this is the first study showing the positive correlation between Sydenham\u2019s chorea and neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios. Further studies are needed to confirm this hypothesis, as this is the first study in the literature on this topic.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s104795112000089x","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T09:42:07Z","timestamp":1588585327000},"page":"717-721","source":"Crossref","is-referenced-by-count":20,"title":["Are there any novel markers in acute rheumatic fever: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-4052","authenticated-orcid":false,"given":"Dilek","family":"Giray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olgu","family":"Hallioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"S104795112000089X_ref22","first-page":"1002","article-title":"A review of neutrophil-lymphocyte, monocyte- lymphocyte, and platelet-lymphocyte ratios use in psychiatric disorders","volume":"1","author":"Mazza","year":"2018","journal-title":"World J Depress Anxiety"},{"key":"S104795112000089X_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.12.001"},{"key":"S104795112000089X_ref19","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2015.60533"},{"key":"S104795112000089X_ref15","doi-asserted-by":"publisher","DOI":"10.1177\/1076029612452116"},{"key":"S104795112000089X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.04.019"},{"key":"S104795112000089X_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.05.005"},{"key":"S104795112000089X_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1981.tb00171.x"},{"key":"S104795112000089X_ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.415"},{"key":"S104795112000089X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2019.02.003"},{"key":"S104795112000089X_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/1076029613475474"},{"key":"S104795112000089X_ref16","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2018-031"},{"key":"S104795112000089X_ref21","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000161840.62090.0E"},{"key":"S104795112000089X_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000232634.55883.d0"},{"key":"S104795112000089X_ref17","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S82423"},{"key":"S104795112000089X_ref7","first-page":"1","article-title":"Rheumatic fever and rheumatic heart disease: report of a WHO expert consultation. 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WHO Technical Report Series","volume":"923","author":"Bisno","year":"2004","journal-title":"World Health Organ Tech Rep Ser"},{"key":"S104795112000089X_ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021333"},{"key":"S104795112000089X_ref18","article-title":"The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio acute rheumatic fever in children with cardiac involvement","author":"Buyukoflaz","year":"2018","journal-title":"J Clin Anal Med"},{"key":"S104795112000089X_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-1229(05)80019-4"},{"key":"S104795112000089X_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02462.x"},{"key":"S104795112000089X_ref3","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2013rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratislavske Lekarske Listy"},{"key":"S104795112000089X_ref23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.1.73"},{"key":"S104795112000089X_ref13","first-page":"3438","article-title":"Association of neutrophil\/lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention","volume":"123","author":"Shen","year":"2010","journal-title":"Chin Med J"},{"key":"S104795112000089X_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835c2af3"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795112000089X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T11:40:06Z","timestamp":1589888406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795112000089X\/type\/journal_article"}},"subtitle":["Novel Indexes in Acute Rheumatic Fever?"],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S104795112000089X"],"URL":"https:\/\/doi.org\/10.1017\/s104795112000089x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}