{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:08:24Z","timestamp":1759774104262,"version":"3.40.5"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951120001365_as1\" sec-type=\"other\"><jats:title>Objective:<\/jats:title><jats:p>To determine the prevalence of pacemaker and conduction disturbances in patients with atrial septal defects.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120001365_as2\" sec-type=\"other\"><jats:title>Design:<\/jats:title><jats:p>All patients with an atrial septal defect born before 1994 were identified in the Danish National Patient Registry, and 297 patients were analysed for atrioventricular block, bradycardia, right bundle branch block, left anterior fascicular block, left posterior fascicular block, pacemaker, and mortality. Our results were compared with pre-existing data from a healthy background population. Further, outcomes were compared between patients with open atrial septal defects and atrial septal defects closed by surgery or transcatheter.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120001365_as3\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>Most frequent findings were incomplete right bundle branch block (40.1%), left anterior fascicular block (3.7%), atrioventricular block (3.7%), and pacemaker (3.7%). Average age at pacemaker implantation was 32 years. Patients with defects closed surgically or by transcatheter had an increased prevalence of atrioventricular block (p &lt; 0.01), incomplete right bundle branch block (p &lt; 0.01), and left anterior fascicular block (p = 0.02) when compared to patients with unclosed atrial septal defects. At age above 25 years, there was a considerably higher prevalence of atrioventricular block (9.4% versus 0.1%) and complete right bundle branch block (1.9% versus 0.4%) when compared to the background cohorts.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120001365_as4\" sec-type=\"other\"><jats:title>Conclusions:<\/jats:title><jats:p>Patients with atrial septal defects have a considerably higher prevalence of conduction abnormalities when compared to the background population. Patients with surgically or transcatheter closed atrial septal defects demonstrated a higher demand for pacemaker and a higher prevalence of atrioventricular block, incomplete right bundle branch block, and left anterior fascicular block when compared to patients with unclosed atrial septal defects.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951120001365","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T07:20:48Z","timestamp":1591341648000},"page":"980-985","source":"Crossref","is-referenced-by-count":8,"title":["Pacemaker and conduction disturbances in patients with atrial septal defect"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-7193","authenticated-orcid":false,"given":"Diana H. R.","family":"Alb\u00e6k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Udholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sif L.","family":"Ovesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarmiga","family":"Karunanithi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Nyboe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke E.","family":"Hjortdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"S1047951120001365_ref15","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.6.625"},{"key":"S1047951120001365_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"S1047951120001365_ref14","volume-title":"Medicinsk kompendium","volume":"18","author":"Ove","year":"2013"},{"key":"S1047951120001365_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313758"},{"key":"S1047951120001365_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23051"},{"key":"S1047951120001365_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.02.024"},{"key":"S1047951120001365_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht511"},{"key":"S1047951120001365_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306552"},{"key":"S1047951120001365_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.10.015"},{"key":"S1047951120001365_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.03.063"},{"key":"S1047951120001365_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62145-5"},{"key":"S1047951120001365_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx687"},{"key":"S1047951120001365_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12317"},{"key":"S1047951120001365_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00405-2"},{"key":"S1047951120001365_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592055"},{"key":"S1047951120001365_ref13","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1161\/circ.104.25.3169","article-title":"ACC\/AHA clinical competence statement on electrocardiography and ambulatory electrocardiography: a report of the American College of Cardiology\/American Heart Association\/American College of Physicians \u2013 American Society of Internal Medicine Task Force on Clinical Competence (ACC\/AHA Committee to Develop a Clinical Competence Statement on Electrocardiography and Ambulatory Electrocardiography)","volume":"104","author":"Kadish","year":"2001","journal-title":"Circulation"},{"key":"S1047951120001365_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/heartasia-2016-010745"},{"key":"S1047951120001365_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S104795110400112X"},{"key":"S1047951120001365_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs291"},{"key":"S1047951120001365_ref20","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304225"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951120001365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:34:40Z","timestamp":1595932480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951120001365\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,5]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1047951120001365"],"URL":"https:\/\/doi.org\/10.1017\/s1047951120001365","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2020,6,5]]}}}