{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:26:50Z","timestamp":1784849210664,"version":"3.55.0"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951120001912_as1\"><jats:title>Background:<\/jats:title><jats:p>Pre-mature birth impacts left ventricular development, predisposing this population to long-term cardiovascular risk. The aims of this study were to investigate maturational changes in rotational properties from the neonatal period through 1 year of age and to discern the impact of cardiopulmonary complications of pre-maturity on these measures.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120001912_as2\"><jats:title>Methods:<\/jats:title><jats:p>Pre-term infants (&lt;29 weeks at birth, n = 117) were prospectively enrolled and followed to 1-year corrected age. Left ventricular basal and apical rotation, twist, and torsion were measured by two-dimensional speckle-tracking echocardiography and analysed at 32 and 36 weeks post-menstrual age and 1-year corrected age. A mixed random effects model with repeated measures analysis was used to compare rotational mechanics over time. Torsion was compared in infants with and without complications of cardiopulmonary diseases of pre-maturity, specifically bronchopulmonary dysplasia, pulmonary hypertension, and patent ductus arteriosus.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120001912_as3\"><jats:title>Results:<\/jats:title><jats:p>Torsion decreased from 32 weeks post-menstrual age to 1-year corrected age in all pre-term infants (p &lt; 0.001). The decline from 32 to 36 weeks post-menstrual age was more pronounced in infants with cardiopulmonary complications, but was similar to healthy pre-term infants from 36 weeks post-menstrual age to 1-year corrected age. The decline was due to directional and magnitude changes in apical rotation over time (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120001912_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>This study tracks maturational patterns of rotational mechanics in pre-term infants and reveals torsion declines from the neonatal period through 1 year. Cardiopulmonary diseases of pre-maturity may negatively impact rotational mechanics during the neonatal period, but the myocardium recovers by 1-year corrected age.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951120001912","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T08:29:28Z","timestamp":1594801768000},"page":"1238-1246","source":"Crossref","is-referenced-by-count":7,"title":["Maturational patterns of left ventricular rotational mechanics in pre-term infants through 1 year of age"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5170-5014","authenticated-orcid":false,"given":"Gloria C.","family":"Lehmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-5834","authenticated-orcid":false,"given":"Philip T.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna D.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Sekarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongJie","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Choudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Hamvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"S1047951120001912_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.06.005"},{"key":"S1047951120001912_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.96"},{"key":"S1047951120001912_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.574"},{"key":"S1047951120001912_ref46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.126920"},{"key":"S1047951120001912_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-015-0250-8"},{"key":"S1047951120001912_ref44","first-page":"H1053","article-title":"Independent effects of preload, afterload, and contractility on left ventricular torsion","volume":"277","author":"Dong","year":"1999","journal-title":"Am J Physiol"},{"key":"S1047951120001912_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.754424"},{"key":"S1047951120001912_ref37","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.24.3.339"},{"key":"S1047951120001912_ref38","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14442"},{"key":"S1047951120001912_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-019-0712-9"},{"key":"S1047951120001912_ref15","first-page":"H571","article-title":"Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dog","volume":"269","author":"LeGrice","year":"1995","journal-title":"Am J Physiol"},{"key":"S1047951120001912_ref35","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12463"},{"key":"S1047951120001912_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.017"},{"key":"S1047951120001912_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1277-3"},{"key":"S1047951120001912_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.03.011"},{"key":"S1047951120001912_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.10.002"},{"key":"S1047951120001912_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2014.09.004"},{"key":"S1047951120001912_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"S1047951120001912_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.572"},{"key":"S1047951120001912_ref40","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq078"},{"key":"S1047951120001912_ref29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.142"},{"key":"S1047951120001912_ref34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106504"},{"key":"S1047951120001912_ref42","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2015.45.2.131"},{"key":"S1047951120001912_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.324"},{"key":"S1047951120001912_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.01.024"},{"key":"S1047951120001912_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.02.015"},{"key":"S1047951120001912_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12716"},{"key":"S1047951120001912_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.537639"},{"key":"S1047951120001912_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq104"},{"key":"S1047951120001912_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.1327"},{"key":"S1047951120001912_ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000445779"},{"key":"S1047951120001912_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007742"},{"key":"S1047951120001912_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0080-2"},{"key":"S1047951120001912_ref14","first-page":"913","article-title":"EL-Khuffash a. The effect of antenatal magnesium sulfate on left ventricular afterload and myocardial function measured using deformation and rotational mechanics imaging","volume":"35","author":"James","year":"2015","journal-title":"Pediatr Res"},{"key":"S1047951120001912_ref45","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13880"},{"key":"S1047951120001912_ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0346-3"},{"key":"S1047951120001912_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.02.006"},{"key":"S1047951120001912_ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000440940"},{"key":"S1047951120001912_ref25","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201504-218OC"},{"key":"S1047951120001912_ref36","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.3.248"},{"key":"S1047951120001912_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.03.015"},{"key":"S1047951120001912_ref41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2010.01226.x"},{"key":"S1047951120001912_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.10.015"},{"key":"S1047951120001912_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.03.003"},{"key":"S1047951120001912_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13421"},{"key":"S1047951120001912_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.07.001"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951120001912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T05:45:49Z","timestamp":1602481549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951120001912\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1047951120001912"],"URL":"https:\/\/doi.org\/10.1017\/s1047951120001912","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]}}}