{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:01:23Z","timestamp":1776988883130,"version":"3.51.4"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951120002425_as1\"><jats:title>Introduction and aim:<\/jats:title><jats:p>Hydroxychloroquine alone or in combination with azithromycin has been increasingly used for patients with coronavirus disease 2019, in both children and adults. Drugs are generally well tolerated in clinical practice; however, both can cause corrected QT prolongation. We aimed to report our experience of QT interval evaluation associated with the use of hydroxychloroquine with concurrent azithromycin among children testing positive for coronavirus disease 2019.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120002425_as2\"><jats:title>Methods:<\/jats:title><jats:p>Our single-centre; retrospective, study evaluated children with coronavirus disease 2019 disease admitted to the Pediatric Department at Sancaktepe Training and Research Hospital Istanbul, Turkey from 10 March, 2020 to 10 April, 2020. The data including demographics, clinical symptoms, co-morbid diseases, laboratory, radiological findings as well as electrocardiographs of the patients were obtained from our records. Electrocardiograms were evaluated before, one day after and at the termination of the treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120002425_as3\"><jats:title>Results:<\/jats:title><jats:p>21 patients aged 9 to 18 years were evaluated. The median age was 170 months (range 112\u2013214), 51.1% of them were girls and 48.9% were boys. Their laboratory results did not reveal any abnormalities. None of them needed intensive care. We did not detect QT prolongation during or at the termination of the treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120002425_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>We did not detect QT prolongation during or at the termination of the treatment in our patients due to the fact that they were not severely affected by the disease. Patients were treated in our inpatient clinic and none of them required intensive care. Laboratory results were also insignificant. Furthermore, they did not need other medications.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951120002425","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T09:17:56Z","timestamp":1595236676000},"page":"1482-1485","source":"Crossref","is-referenced-by-count":10,"title":["QT interval evaluation associated with the use of hydroxychloroquine with combined use of azithromycin among hospitalised children positive for coronavirus disease 2019"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2558-8851","authenticated-orcid":false,"given":"Tunc","family":"Tuncer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysun","family":"Boga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilal","family":"Durmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirin","family":"Guven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"S1047951120002425_ref11","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1310\/hpj5110-830","article-title":"Impact of the fda warning for azithromycin and risk for qt prolongation on utilization at an academic medical center","volume":"51","author":"Dunker","year":"2016","journal-title":"Hosp Pharm"},{"key":"S1047951120002425_ref2","first-page":"422","article-title":"Coronavirus Disease 2019 in Children \u2014 United States","volume":"69","year":"2020","journal-title":"Morb Mortal Weekly Rep"},{"key":"S1047951120002425_ref9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1473-3099(07)70187-1","article-title":"Cardiotoxicity of antimalarial drugs","volume":"7","author":"White","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"S1047951120002425_ref6","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1056\/NEJMoa1003833","article-title":"Azithromycin and the risk of cardiovascular death","volume":"366","author":"Ray","year":"2012","journal-title":"N Engl J Med"},{"key":"S1047951120002425_ref5","unstructured":"5. Malaria Policy Advisory Committee Meeting, World Health Organization. The cardiotoxicity of antimalarials. 22\u201324 March 2017, Geneva, Switzerland."},{"key":"S1047951120002425_ref12","doi-asserted-by":"crossref","first-page":"e008662","DOI":"10.1161\/CIRCEP.120.008662","article-title":"The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection","volume":"13","author":"Saleh","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"S1047951120002425_ref7","doi-asserted-by":"crossref","first-page":"1574806","DOI":"10.1155\/2018\/1574806","article-title":"Risk evaluation of azithromycin-induced qt prolongation in real-world practice","volume":"2018","author":"Choi","year":"2018","journal-title":"Biomed Res Int"},{"key":"S1047951120002425_ref4","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.367.6485.1412","article-title":"Race to find COVID-19 treatments accelerates","volume":"367","author":"Kupferschmidt","year":"2020","journal-title":"Science"},{"key":"S1047951120002425_ref16","doi-asserted-by":"crossref","unstructured":"16. Wu, C-I , Postema, PG , Arbelo, E et al. SARS-CoV-2, COVID-19, and inherited arrhythmia syndromes. Heart Rhythm. 2020 Mar 31. [Epub ahead of print]. https:\/\/doi.org\/10.1016\/j.hrthm.2020.03.024.","DOI":"10.1016\/j.hrthm.2020.03.024"},{"key":"S1047951120002425_ref15","unstructured":"15. Simpson, TF , Kovacs, RJ , Stecker, EC . Ventricular arrhythmia risk due to hydroxychloroquine-azithromycin treatment For COVID-19. JACC 2020 Mar 29 [Epub ahead of print]."},{"key":"S1047951120002425_ref10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1517\/14740338.2015.989210","article-title":"Cardiac risks associated with antibiotics: azithromycin and levofloxacin","volume":"14","author":"Lu","year":"2015","journal-title":"Expert Opin Drug Saf."},{"key":"S1047951120002425_ref13","first-page":"e201834","article-title":"Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)","volume":"2020","author":"Mercuro","year":"2020","journal-title":"JAMA Cardiol"},{"key":"S1047951120002425_ref8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12916-018-1188-2","article-title":"The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review","volume":"16","author":"Haeusler","year":"2018","journal-title":"BMC Med"},{"key":"S1047951120002425_ref1","doi-asserted-by":"crossref","first-page":"e20200702","DOI":"10.1542\/peds.2020-0702","article-title":"Epidemiology of COVID-19 among children in China","volume":"145","author":"Dong","year":"2020","journal-title":"Pediatrics"},{"key":"S1047951120002425_ref3","doi-asserted-by":"crossref","first-page":"P689","DOI":"10.1016\/S1473-3099(20)30198-5","article-title":"Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study","volume":"20:","author":"Qiu","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"S1047951120002425_ref14","doi-asserted-by":"crossref","unstructured":"14. Chorin, E , Wadhwani, L , Magnani, S et\u00a0al. QT interval prolongation and Torsade de pointes in patients with COVID-19 treated with hydroxychloroquine\/azithromycin. Heart Rhythm 2020 May 11. [Epub ahead of print]. https:\/\/doi.org\/10.1016\/j.hrthm.2020.05.014.","DOI":"10.1016\/j.hrthm.2020.05.014"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951120002425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:21:53Z","timestamp":1602739313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951120002425\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1047951120002425"],"URL":"https:\/\/doi.org\/10.1017\/s1047951120002425","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]}}}