{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:59:46Z","timestamp":1747173586234,"version":"3.40.5"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951120002930_as1\"><jats:title>Background:<\/jats:title><jats:p>Brucellosis is an important systemic infectious disease, especially in developing countries. Every organ and system of the human body can be affected; however, cardiovascular complications of brucellosis are rare.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120002930_as2\"><jats:title>Aim:<\/jats:title><jats:p>To assess cardiac functions in patients with acute brucellosis without overt cardiac involvement and to answer the following question: Is there any cardiac dysfunction despite the absence of endocarditis in these patients?<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120002930_as3\"><jats:title>Methods:<\/jats:title><jats:p>This cross-sectional study included 67 children with brucellosis and 40 healthy children. We performed a detailed echocardiographic examination in individuals at the beginning of the treatment. Patients with infective endocarditis were excluded from the study.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120002930_as4\"><jats:title>Results:<\/jats:title><jats:p>Echocardiography revealed no difference of ejection fraction, mitral and tricuspid annular plane systolic excursion, pulsed-wave Doppler-derived early diastolic peak velocity (E)\/late diastolic peak velocity (A) ratios in mitral and tricuspid valves between the two groups. The deceleration time of early mitral inflow was longer in patients with brucellosis. Early diastolic peak velocity of the mitral and tricuspid annuluses obtained by tissue Doppler imaging (Ea) was significantly lower in children with brucellosis. The peak velocity obtained by tissue Doppler imaging during late diastole (Aa), Ea and Ea\/Aa ratios in the interventricular septum, left ventricle posterior wall and right ventricle free wall was lower in patients with brucellosis than in the control group. The E\/Ea ratio, isovolumic relaxation time, right ventricle and left ventricle myocardial performance indices were higher in patients with brucellosis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120002930_as5\"><jats:title>Conclusion:<\/jats:title><jats:p>Patients with acute brucellosis may have diastolic dysfunction without overt cardiac involvement and infective endocarditis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951120002930","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T06:20:50Z","timestamp":1600237250000},"page":"1840-1843","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Diastolic dysfunction in patients with brucellosis despite the absence of infective endocarditis"],"prefix":"10.1017","volume":"30","author":[{"given":"\u0130brahim","family":"Ece","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-0063","authenticated-orcid":false,"given":"Serdar","family":"Ep\u00e7a\u00e7an","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcls\u00fcm \u0130clal","family":"Bayhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"T\u00fcre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"S1047951120002930_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.06.031"},{"key":"S1047951120002930_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/clc.3"},{"key":"S1047951120002930_ref6","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2010-031"},{"key":"S1047951120002930_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90258-3"},{"key":"S1047951120002930_ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1788"},{"key":"S1047951120002930_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91004-6"},{"key":"S1047951120002930_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90453-R"},{"key":"S1047951120002930_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-010-0469-3"},{"key":"S1047951120002930_ref7","first-page":"375","volume-title":"Echocardiography","author":"Garson","year":"2006"},{"key":"S1047951120002930_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00344-6"},{"key":"S1047951120002930_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(96)90476-9"},{"key":"S1047951120002930_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)88335-0"},{"key":"S1047951120002930_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.11.007"},{"key":"S1047951120002930_ref3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.24953\/turkjped.2011.1793","article-title":"Clinical and laboratory features, complications and treatment outcome of brucellosis in childhood and review of the literature","volume":"53","author":"Ulu\u011f","year":"2011","journal-title":"Turk J Pediatr"},{"key":"S1047951120002930_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"S1047951120002930_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01047-X"},{"key":"S1047951120002930_ref16","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: a simple and reproducible measurement of cardiac function-a study in normal and dilated cardiomyopathy","volume":"26","author":"Tei","year":"1995","journal-title":"J Cardiol"},{"key":"S1047951120002930_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1026-z"},{"key":"S1047951120002930_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199607000-00003"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951120002930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T22:07:23Z","timestamp":1723586843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951120002930\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1047951120002930"],"URL":"https:\/\/doi.org\/10.1017\/s1047951120002930","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2020,9,16]]},"assertion":[{"value":"\u00a9 The Author(s), 2020. 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