{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:06:15Z","timestamp":1788257175294,"version":"build-2803163510"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951120003984_as1\"><jats:title>Objective:<\/jats:title><jats:p>To analyse the changes of different ventilation on regional cerebral oxygen saturation and cerebral blood flow in infants during ventricular septal defect repair.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120003984_as2\"><jats:title>Methods:<\/jats:title><jats:p>Ninety-two infants younger than 1 year were enrolled in the study. End-expiratory tidal pressure of carbon dioxide was maintained at 40\u201345 and 35\u201339\u00a0mmHg in relative low and high ventilation groups. Regional cerebral oxygen saturation and flow velocity of the middle cerebral artery were recorded after anaesthesia (T0), cut pericardium (T1), separation from cardiopulmonary bypass (T2), the end of modified ultrafiltration, (T3) and at the end of operation (T4).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120003984_as3\"><jats:title>Results:<\/jats:title><jats:p>The relative low ventilation group exhibited a significantly high regional cerebral oxygen saturation at each time point except for T2 (T0:77 \u00b1 4, T1:76 \u00b1 5, T3:76 \u00b1 8, T4:76 \u00b1 8, respectively, p &lt; 0.001). Flow velocity of the middle cerebral artery in the relative low ventilation group was higher compared to the relative high ventilation group at each time point except for T2 (T0:53 \u00b1 14, T1:54 \u00b1 15, T3:53 \u00b1 17, T4:52 \u00b1 16, respectively, p &lt; 0.001). Between the two groups, T2 showed the lowest middle cerebral artery flow velocity (relative low ventilation: 39 \u00b1 15, relative high ventilation: 39 \u00b1 11, p &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120003984_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>The infants\u2019 regional cerebral oxygen saturation and middle cerebral artery flow velocity performed better in the range of 40\u201345\u00a0mmHg end-expiratory tidal pressure of carbon dioxide during CHD surgery. Modified ultrafiltration increased cerebral oxygen saturation. It was important to regulate ventilation in order to balance cerebral oxygen in infants.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951120003984","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T22:20:38Z","timestamp":1612563638000},"page":"371-376","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Effects of different ventilation on cerebral oxygen saturation and cerebral blood flow before and after modified ultrafiltration in infants during ventricular septal defect repair"],"prefix":"10.1017","volume":"31","author":[{"given":"Boqun","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Ou-Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duomao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9934-6567","authenticated-orcid":false,"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"S1047951120003984_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.12.058"},{"key":"S1047951120003984_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.02.096"},{"key":"S1047951120003984_ref21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.828"},{"key":"S1047951120003984_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh120"},{"key":"S1047951120003984_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.146290"},{"key":"S1047951120003984_ref23","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1487"},{"key":"S1047951120003984_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14065"},{"key":"S1047951120003984_ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2013.05.008"},{"key":"S1047951120003984_ref30","first-page":"1929","article-title":"Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography","volume":"18","author":"Valdueza","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"S1047951120003984_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001898"},{"key":"S1047951120003984_ref3","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134808.52676.4D"},{"key":"S1047951120003984_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000055"},{"key":"S1047951120003984_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12307"},{"key":"S1047951120003984_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03430.x"},{"key":"S1047951120003984_ref29","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199305000-00006"},{"key":"S1047951120003984_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/0267659106071317"},{"key":"S1047951120003984_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12166"},{"key":"S1047951120003984_ref24","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.4.625"},{"key":"S1047951120003984_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0457-x"},{"key":"S1047951120003984_ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S104795110400407X"},{"key":"S1047951120003984_ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2000.06487.x"},{"key":"S1047951120003984_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.5.813"},{"key":"S1047951120003984_ref17","unstructured":"17. 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