{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:57:47Z","timestamp":1747173467144,"version":"3.40.5"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951120004175_as1\"><jats:title>Introduction:<\/jats:title><jats:p>Children with congenital heart disease and cardiomyopathy are a unique patient population. Different therapies continue to be introduced with large practice variability and questionable outcomes. The purpose of this study is to determine the impact of various medications on intensive care unit length of stay, total length of stay, billed charges, and mortality for admissions with congenital heart disease and cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120004175_as2\"><jats:title>Materials and methods:<\/jats:title><jats:p>We identified admissions of paediatric patients with cardiomyopathy using the Pediatric Health Information System database. The admissions were then separated into two groups: those with and without inpatient mortality. Univariate analyses were conducted between the groups and the significant variables were entered as independent variables into the regression analyses.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120004175_as3\"><jats:title>Results:<\/jats:title><jats:p>A total of 10,376 admissions were included these analyses. Of these, 904 (8.7%) experienced mortality. Comparing patients who experienced mortality with those who did not, there was increased rate of acute kidney injury with an odds ratio (OR) of 5.0 [95% confidence interval (CI) 4.3 to 5.8, p &lt; 0.01], cardiac arrest with an OR 7.5 (95% CI 6.3 to 9.0, p &lt; 0.01), and heart transplant with an OR 0.3 (95% CI 0.2 to 0.4, p &lt; 0.01). The medical interventions with benefit for all endpoints after multivariate regression analyses in this cohort are methylprednisolone, captopril, enalapril, furosemide, and amlodipine.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951120004175_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Diuretics, steroids, angiotensin-converting enzyme inhibitors, calcium channel blockers, and beta blockers all appear to offer beneficial effects in paediatric cardiomyopathy admission outcomes. Specific agents within each group have varying effects.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951120004175","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T06:17:20Z","timestamp":1608099440000},"page":"406-413","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["The impact of medical interventions on admission characteristics in children with congenital heart disease and cardiomyopathy"],"prefix":"10.1017","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-2835","authenticated-orcid":false,"given":"Rohit S.","family":"Loomba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Rausa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Dorsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald A.","family":"Bronicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-5192","authenticated-orcid":false,"given":"Enrique G.","family":"Villarreal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-5775","authenticated-orcid":false,"given":"Saul","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"S1047951120004175_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.11.059"},{"key":"S1047951120004175_ref31","first-page":"74","article-title":"Efficacy and safety of carvedilol in infants with dilated cardiomyopathy: a preliminary report","volume":"53","author":"Gachara","year":"2001","journal-title":"Indian Heart J"},{"key":"S1047951120004175_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-016-0267-3"},{"key":"S1047951120004175_ref18","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200608010-00005"},{"key":"S1047951120004175_ref20","unstructured":"20. Allen, HD , Flanigan, KM , Thrush, PT , et al. A randomized, double-blind trial of lisinopril and losartan for the treatment of cardiomyopathy in duchenne muscular dystrophy. PLoS Curr 2013; 5: ecurrents.md.2cc69a1dae4be7dfe2bcb420024ea865."},{"key":"S1047951120004175_ref12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2692"},{"key":"S1047951120004175_ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/595164"},{"key":"S1047951120004175_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-018-1899-1"},{"key":"S1047951120004175_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1330-2"},{"key":"S1047951120004175_ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-012-0954-y"},{"key":"S1047951120004175_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.059"},{"key":"S1047951120004175_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk052"},{"key":"S1047951120004175_ref5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00794837","article-title":"The effect of treatment with angiotensin-converting enzyme inhibitors on survival of pediatric patients with dilated cardiomyopathy","volume":"14","author":"Lewis","year":"1993","journal-title":"Pediatr Cardiol"},{"key":"S1047951120004175_ref23","first-page":"146","article-title":"Hypertrophic cardiomyopathy in pediatric patients: effect of verapamil on regional and global left ventricular diastolic function","volume":"16","author":"Pacileo","year":"2000","journal-title":"Can J Cardiol"},{"key":"S1047951120004175_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2015.1120410"},{"key":"S1047951120004175_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003230"},{"key":"S1047951120004175_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90589-7"},{"key":"S1047951120004175_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0612-2"},{"key":"S1047951120004175_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.05.060"},{"key":"S1047951120004175_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.12.014"},{"key":"S1047951120004175_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.07.025"},{"key":"S1047951120004175_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0527-x"},{"key":"S1047951120004175_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90296-2"},{"key":"S1047951120004175_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-9813(00)00076-X"},{"key":"S1047951120004175_ref25","doi-asserted-by":"crossref","first-page":"366","DOI":"10.12659\/MSM.883911","article-title":"Effects of carvedilol therapy on cardiac autonomic control, QT dispersion, and ventricular arrhythmias in children with dilated cardiomyopathy","volume":"19","author":"Oflaz","year":"2013","journal-title":"Med Sci Monit"},{"key":"S1047951120004175_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008639"},{"key":"S1047951120004175_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.03.033"},{"key":"S1047951120004175_ref24","doi-asserted-by":"publisher","DOI":"10.2174\/1574887109666140908125158"},{"key":"S1047951120004175_ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.52816"},{"key":"S1047951120004175_ref29","first-page":"22","article-title":"Carvedilol therapy in pediatric patients with dilated cardiomyopathy","volume":"51","author":"Askari","year":"2009","journal-title":"Turk J Pediatr"},{"key":"S1047951120004175_ref28","first-page":"354","article-title":"Treatment of dilated cardiomyopathy with carvedilol in children","volume":"51","author":"Erdogan","year":"2009","journal-title":"Turk J Pediatr"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951120004175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T09:56:44Z","timestamp":1662717404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951120004175\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1047951120004175"],"URL":"https:\/\/doi.org\/10.1017\/s1047951120004175","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2020,12,16]]},"assertion":[{"value":"\u00a9 The Author(s), 2020. 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