{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:14Z","timestamp":1786999574640,"version":"build-2736575974"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951121000111_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ascending aortic dilation is a feared complication in adults with repaired coarctation of the aorta, as the condition is associated with life-threatening complications such as aortic dissection and rupture. However, the data are currently limited regarding factors associated with ascending aortic dilation in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951121000111_as2\">\n                    <jats:title>Methods and results:<\/jats:title>\n                    <jats:p>From the national register of congenital heart disease, 165 adult patients (\u2265 18 years old) with repaired coarctation of the aorta, and echocardiographic data on aortic dimensions, were identified (61.2% male, mean age 35.8 \u00b1 14.5 years). Aortic dilation (aortic diameters &gt; 2 SD above reference mean) was found in 55 (33.3%) of the 165 included patients, and was associated with manifest aortic valve disease in univariable logistic regression analysis (OR 2.44, 95% CI [1.23, 4.83]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951121000111_as3\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Aortic dilation is common post-repair of coarctation of the aorta, and is associated with manifest aortic valve disease and thus indirectly with the presence of a bicuspid aortic valve. However, no association was found between aortic dilation and age or blood pressure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951121000111","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T01:54:01Z","timestamp":1613613241000},"page":"992-997","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["High prevalence of ascending aortic dilation in adults with repaired coarctation of the aorta"],"prefix":"10.1017","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-7693","authenticated-orcid":false,"given":"Daniel","family":"Rinnstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Dellborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Thil\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peder","family":"S\u00f6rensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels-Erik","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Christersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"S1047951121000111_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04147-4"},{"key":"S1047951121000111_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1369"},{"key":"S1047951121000111_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.02.014"},{"key":"S1047951121000111_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/heart.88.2.163"},{"key":"S1047951121000111_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02293-7"},{"key":"S1047951121000111_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.12.013"},{"key":"S1047951121000111_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.084"},{"key":"S1047951121000111_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01784-3"},{"key":"S1047951121000111_ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.4.840"},{"key":"S1047951121000111_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.36"},{"key":"S1047951121000111_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.1.81"},{"key":"S1047951121000111_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.07.012"},{"key":"S1047951121000111_ref18","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1093\/eurheartj\/ehq249","article-title":"ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)","volume":"31","author":"Baumgartner","year":"2010","journal-title":"Eur Heart J"},{"key":"S1047951121000111_ref26","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1161\/CIR.0b013e3181d47d48","article-title":"ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine","volume":"121","author":"Hiratzka","year":"2010","journal-title":"Circulation"},{"key":"S1047951121000111_ref22","first-page":"189","article-title":"Coarctation of the aorta in adults: what is the best treatment? 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