{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:03:35Z","timestamp":1773176615685,"version":"3.50.1"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121000482_as1\"><jats:title>Objective:<\/jats:title><jats:p>The aim of this study was to evaluate the safety and efficacy of the Cardi-O-Fix plug used for the treatment of muscular ventricular septal defects.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121000482_as2\"><jats:title>Methods:<\/jats:title><jats:p>We retrospectively reviewed the medical records of five patients with muscular ventricular septal defects who underwent transcatheter closure using the Cardi-O-Fix Plug, from November 2017 to August 2019. The median age was 5.1 years (range: 3.2\u20136.5). Their median body weight was 18.1 kg (range: 13.4\u201321.8). All the patients underwent detailed two-dimensional Doppler and colour flow imaging by transthoracic echocardiography. The left ventricular median defect size of the muscular ventricular septal defects was 5.6 mm (range: 5.3\u20137.0). The right ventricular median defect size of the muscular ventricular septal defects was 3.9 mm (range: 3.3\u20134.7). All the procedures were performed on beating hearts.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121000482_as3\"><jats:title>Results:<\/jats:title><jats:p>All the patients underwent successful device implantation with no displacement or detachment, they have complete echocardiographic closure at the 1-year follow-up. There were no occluder-related arrhythmia, chordae tendineae rupture, tricuspid insufficiency, aortic regurgitation, haemolysis, or embolisation.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121000482_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Application of the Cardi-O-Fix plug appears to be a feasible, safe, and effective treatment option for patients with muscular ventricular septal defects. Longer follow-up periods are warranted to prove the conclusion for long-term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121000482","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T10:52:53Z","timestamp":1613991173000},"page":"1472-1475","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Transcatheter closure of muscular ventricular septal defects using the Cardi-O-Fix plug"],"prefix":"10.1017","volume":"31","author":[{"given":"Zhisong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huasheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-5089","authenticated-orcid":false,"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"S1047951121000482_ref5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ihj.2017.08.001","article-title":"Contemporary outcomes of percutaneous closure of patent ductus arteriosus in adolescents and adults","volume":"70","author":"Sudhakar","year":"2018","journal-title":"Indian Heart J"},{"key":"S1047951121000482_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2010.12.012"},{"key":"S1047951121000482_ref8","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ccd.25177","article-title":"Transvascular closure of single and multiple muscular ventricular septal defects in neonates and infants < 20 kg","volume":"83","author":"Peter","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951121000482_ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8948249"},{"key":"S1047951121000482_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2017.11.023"},{"key":"S1047951121000482_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-019-00289-5"},{"key":"S1047951121000482_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115002206"},{"key":"S1047951121000482_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.06.020"},{"key":"S1047951121000482_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0218492316645746"},{"key":"S1047951121000482_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2005.02.005"},{"key":"S1047951121000482_ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.2.361"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951121000482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T10:48:23Z","timestamp":1641811703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951121000482\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1047951121000482"],"URL":"https:\/\/doi.org\/10.1017\/s1047951121000482","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}