{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:39:07Z","timestamp":1757781547435,"version":"3.40.5"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121000585_as1\"><jats:title>Background:<\/jats:title><jats:p>Although cardiac catheterisation (cath) is the diagnostic test for pulmonary hypertension, it is an invasive procedure. Echocardiography (echo) is commonly used for the non-invasive diagnosis of pulmonary hypertension but maybe limited by lack of adequate signals. Therefore, emphasis has been placed on biomarkers as a potential diagnostic tool. No prior paediatric studies have simultaneously compared N-terminal pro-B-type-natriuretic peptide (NTproBNP) with cath\/echo as a potential diagnostic tool. The aim of this study was to determine if NTproBNP was a reliable diagnostic tool for pulmonary hypertension in this population.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121000585_as2\"><jats:title>Methods:<\/jats:title><jats:p>Patients were divided into Study (echo evidence\/established diagnosis of pulmonary hypertension undergoing cath) and Control (cath for small atrial septal defect\/patent ductus arteriosus and endomyocardial biopsy post cardiac transplant) groups. NTproBNP, cath\/echo data were obtained.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121000585_as3\"><jats:title>Results:<\/jats:title><jats:p>Thirty-one patients met inclusion criteria (10 Study, 21 Control<jats:italic>).<\/jats:italic> Median NTproBNP was significantly higher in the Study group. Echo parameters including transannular plane systolic excursion z scores, pulmonary artery acceleration time and right ventricular fractional area change were lower in the Study group and correlated negatively with NTproBNP. Receiver operation characteristic curve analysis demonstrated NTproBNP &gt; 389 pg\/ml was 87% specific for the diagnosis of pulmonary hypertension with the addition of pulmonary artery acceleration time improving the specificity.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121000585_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>NTproBNP may be a valuable adjunctive diagnostic tool for pulmonary hypertension in the paediatric population. Echo measures of transannular plane systolic excursion z score, pulmonary artery acceleration time and right ventricular fractional area change had negative correlations with NTproBNP. The utility of NTproBNP as a screening tool for pulmonary hypertension requires validation in a population with unknown pulmonary hypertension status.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121000585","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:24:55Z","timestamp":1614680695000},"page":"1595-1607","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["N-terminal pro-B-type-natriuretic peptide as a screening tool for pulmonary hypertension in the paediatric 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