{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:58:10Z","timestamp":1747173490697,"version":"3.40.5"},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alveolar capillary dysplasia with misalignment of the pulmonary veins is an uncommon disorder that affects the lung vasculature development in the neonatal period and leads to pulmonary hypertension. We describe two patients with alveolar capillary dysplasia associated with left-sided obstructive heart defects with two different genetic variants. Our cases highlight the importance of early recognition of this disease in the setting of persistent and supra-systemic pulmonary hypertension despite surgical correction of the associated lesions. Identification of these cases will facilitate the development of a multidisciplinary approach and provide guidance to the affected families.<\/jats:p>","DOI":"10.1017\/s1047951121000676","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T02:38:55Z","timestamp":1614911935000},"page":"1368-1370","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Two cases of different genetic variants of alveolar capillary dysplasia associated with left-sided obstructive CHDs"],"prefix":"10.1017","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-1801","authenticated-orcid":false,"given":"Josue","family":"Diaz-Frias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Oliver","family":"Aregullin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"S1047951121000676_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-317121"},{"key":"S1047951121000676_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.10.026"},{"key":"S1047951121000676_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308591"},{"key":"S1047951121000676_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112001904"},{"key":"S1047951121000676_ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1697CI"},{"key":"S1047951121000676_ref4","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-17119"},{"key":"S1047951121000676_ref6","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/ajmg.a.61162","article-title":"Alveolar capillary dysplasia with misalignment of the pulmonary veins and hypoplastic left heart sequence caused by an in-frame deletion within FOXF1","volume":"179","author":"Bourque","year":"2019","journal-title":"Am J Med Genet A"},{"key":"S1047951121000676_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2020.107289"},{"key":"S1047951121000676_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-016-1655-9"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951121000676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T11:58:32Z","timestamp":1697975912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951121000676\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1047951121000676"],"URL":"https:\/\/doi.org\/10.1017\/s1047951121000676","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}