{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:24:33Z","timestamp":1778081073250,"version":"3.51.4"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121001116_as1\"><jats:title>Background:<\/jats:title><jats:p>Pulmonary vascular damage may be associated with oxidative stress in congenital heart diseases. We investigated whether small ventricular septal defects have an effect on the pulmonary bed.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121001116_as2\"><jats:title>Methods:<\/jats:title><jats:p>This prospective cohort study included 100 patients with small ventricular septal defects and 75 healthy controls. Ischemia-modified albumin, high-sensitivity C-reactive protein, and various cardiovascular parameters were assessed in both groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121001116_as3\"><jats:title>Results:<\/jats:title><jats:p>The mean ischemia-modified albumin level was significantly higher in patients with small ventricular septal defects (0.62 \u00b1 0.17 absorbance units) than in the control group (0.51 \u00b1 0.09 absorbance units; p &lt; 0.001). The mean high-sensitivity C-reactive protein level was significantly higher in the ventricular septal defects group (3.72 \u00b1 1.57) than in the control group (2.45 \u00b1 0.89; p &lt; 0.001). The ischemia-modified albumin levels in patients with left ventricular internal diameter end diastole and end sistole and main pulmonary artery z-scores \u2265 2 were significantly higher than patients whose z-scores were &lt;2. The ischemia-modified albumin and high-sensitivity C-reactive protein levels were positively correlated in the small ventricular septal defects group (rho = 0.742, p &lt; 0.001). Receiver operating characteristic analyses showed that at the optimal cut-off value of ischemia-modified albumin for the prediction of pulmonary involvement was 0.55 absorbance units with a sensitivity of 60%, specificity of 62% (area under the curve = 0.690, p &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121001116_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>We demonstrated the presence of oxidative stress and higher ischemia-modified albumin levels in small ventricular septal defects, suggesting that ischemia-modified albumin might be a useful biomarker for evaluating the effects of small ventricular septal defects on the pulmonary bed.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121001116","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T05:53:40Z","timestamp":1616392420000},"page":"1207-1212","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Usefulness of ischemia-modified albumin for assessment of the effects of small ventricular septal defects on the pulmonary vascular 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