{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:07:24Z","timestamp":1770458844645,"version":"3.49.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121001360_as1\"><jats:title>Aim:<\/jats:title><jats:p>Growth differentiation factor-15 is a novel biomarker of increasing importance in cardiovascular diseases. This study aimed to evaluate the relationship between ventricular measurements assessed by cardiac magnetic resonance imaging (MRI) and serum growth differentiation factor-15 levels in children with surgically corrected tetralogy of Fallot.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121001360_as2\"><jats:title>Materials and method:<\/jats:title><jats:p>Serum growth differentiation factor-15 levels were measured in 40 patients (mean age: 15.2 \u00b1 2.9 years; 52.5% male; 87.5% NYHA I). End-diastolic volume index, end-systolic volume index, and ejection fractions of both ventricles and pulmonary regurgitation fraction were measured on cardiac MRI. The correlation between growth differentiation factor-15 levels and cardiac MRI parameters of the patients was investigated. Also, growth differentiation factor-15 levels of the patients were compared with healthy controls since reference values have not been determined in children.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121001360_as3\"><jats:title>Results:<\/jats:title><jats:p>The mean growth differentiation factor-15 level was 254.9 \u00b1 6.3 pg\/ml in the patient group. There was no correlation between growth differentiation factor-15 levels and cardiac MRI parameters in patients. Also, there was no significant difference in growth differentiation factor-15 levels between the patients and control groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121001360_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>The serum levels of growth differentiation factor-15 were uncorrelated with ventricular size, function, and pulmonary regurgitation fraction assessed by cardiac MRI in children with operated tetralogy of Fallot. Moreover, growth differentiation factor-15 levels were not different in these patients from healthy children.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121001360","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T06:44:29Z","timestamp":1617864269000},"page":"1969-1974","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the relationship between ventricular function and serum growth differentiation factor-15 levels in patients with operated tetralogy of Fallot"],"prefix":"10.1017","volume":"31","author":[{"given":"Damla","family":"\u00d6nal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-0670","authenticated-orcid":false,"given":"Ay\u015fe G.","family":"Ero\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazl\u0131 G.","family":"Akyel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra K.","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Karaka\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl Z.","family":"Pirdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Adaletli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"S1047951121001360_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.07.634"},{"key":"S1047951121001360_ref2","first-page":"e698","article-title":"2018 AHA\/ACC Guideline for the management of adults with congenital heart disease: a report of the 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in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951121001360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T15:13:10Z","timestamp":1644333190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951121001360\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1047951121001360"],"URL":"https:\/\/doi.org\/10.1017\/s1047951121001360","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"\u00a9 The 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