{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:34:10Z","timestamp":1787312050786,"version":"build-2736575974"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We herein report on a series of four patients presented to our tertiary care centre with features of multisystem inflammatory syndrome in children and cardiac involvement. Two of our patients had recent exposure to a COVID-19-positive patient, one had recent documented infection, and another had no known positive contact. All the patients were tested positive for severe acute respiratory syndrome coronavirus 2 immunoglobulin G antibody at the time of presentation. All of them fulfilled the diagnostic criteria according to the World Health Organization Centers for Disease Control or the British guidelines for MIS-C (fever for \u22653 days, multisystem involvement (at least two), elevated markers of inflammation, and no other alternative diagnosis).<\/jats:p>\n                  <jats:p>Cardiac involvement was variable ranging from isolated ectasia of the coronary arteries to full-blown pancarditis such as severe biventricular dysfunction, multi-valvar involvement, and pericardial effusion.<\/jats:p>\n                  <jats:p>All our patients received intravenous immunoglobulin (2 g\/kg), methylprednisolone, and aspirin and some required inotropic support and ICU admission.<\/jats:p>\n                  <jats:p>Remarkably, all our patients showed significant improvement in their cardiac disease within a few days as evident on serial echocardiographic evaluation. However, we stress the need for long-term follow-up as one of our patients demonstrated mild LV myocardial scarring as evident by gadolinium late enhancement on a cardiac MRI.<\/jats:p>","DOI":"10.1017\/s1047951121002614","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T02:15:14Z","timestamp":1623896114000},"page":"165-168","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac manifestations and short-term outcomes of multisystem inflammatory syndrome in Middle Eastern children during the COVID-19 pandemic: a case series"],"prefix":"10.1017","volume":"32","author":[{"given":"Theresia E.","family":"Tannoury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0893-0435","authenticated-orcid":false,"given":"Ziad R.","family":"Bulbul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-5682","authenticated-orcid":false,"given":"Fadi F.","family":"Bitar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"S1047951121002614_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.694"},{"key":"S1047951121002614_ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"S1047951121002614_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03766-6"},{"key":"S1047951121002614_ref2","unstructured":"2. World Health Organization. Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19, 2020. Retrieved May 15, 2020, from https:\/\/www.who.int\/news-room\/commentaries\/detail\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19"},{"key":"S1047951121002614_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piaa069"},{"key":"S1047951121002614_ref12","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.197046"},{"key":"S1047951121002614_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.06.045"},{"key":"S1047951121002614_ref3","first-page":"918","article-title":"Cardiovascular involvement in Kawasaki disease","volume":"42","author":"Narayanan","year":"2005","journal-title":"Indian Pediatr"},{"key":"S1047951121002614_ref11","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202288"},{"key":"S1047951121002614_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-020-00739-6"},{"key":"S1047951121002614_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30215-7"},{"key":"S1047951121002614_ref6","first-page":"e11064","article-title":"Multisystem inflammatory syndrome in children, the real disease of COVID-19 in pediatrics \u2013 a multicenter case series from Al-Ahsa, Saudi Arabia","volume":"12","author":"Almoosa","year":"2020","journal-title":"Cureus"},{"key":"S1047951121002614_ref10","first-page":"217","article-title":"Abnormal myocardial mechanics in Kawasaki disease: rapid response to gamma-globulin","volume":"139","author":"Moran","year":"2000","journal-title":"Am Heart J"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951121002614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T04:27:16Z","timestamp":1665635236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951121002614\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,17]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1047951121002614"],"URL":"https:\/\/doi.org\/10.1017\/s1047951121002614","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,17]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}