{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:37:29Z","timestamp":1765888649544,"version":"3.40.5"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121002638_as1\"><jats:title>Introduction:<\/jats:title><jats:p>In patients with right ventricular diastolic dysfunction after complete repair of tetralogy of Fallot, some employ the use of beta-blockade. The theoretical benefit of this therapy is felt to be one of the two: 1) reduction in heart rate with subsequent increase in diastolic filling time and stroke volume; 2) halting or reversal of right ventricular remodelling. This study aimed to characterise the use of beta-blockade in paediatric admissions with complete repair of tetralogy of Fallot and characterise the effects of beta-blockade on admission characteristics.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121002638_as2\"><jats:title>Methods:<\/jats:title><jats:p>Admissions from 2004 to 2015 in the Pediatric Health Information System database with complete repair of tetralogy of Fallot were identified. Characteristics between admissions with and without beta-blockade were compared by univariate analysis. Next, regression analyses were conducted to determine the independent association of beta-blockade on length of admission, billed charges, cardiac arrest, and inpatient mortality while controlling for demographic variables and comorbidities.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121002638_as3\"><jats:title>Results:<\/jats:title><jats:p>A total of 3594 admissions were included in the final analyses. Of these, 371 employed beta-blockade. Admissions with beta-blockade were more likely to have heart failure and tachyarrhythmias. These admissions also tended to be longer by univariate analysis. Regression analyses demonstrated that beta-blockade was independently associated with a 2.8-day increase in length of stay and no statistically significant change in billed charges, cardiac arrest, or inpatient mortality.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121002638_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Beta-blockade after complete repair of tetralogy of Fallot is associated with a longer length of stay but did not statistically significantly impact billed charges, cardiac arrest, or inpatient mortality.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121002638","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T02:34:14Z","timestamp":1625711654000},"page":"584-588","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Beta-blocker use after complete repair of tetralogy of Fallot: an analysis of a national database"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-5192","authenticated-orcid":false,"given":"Enrique G.","family":"Villarreal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan S.","family":"Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Tweddell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-2835","authenticated-orcid":false,"given":"Rohit S.","family":"Loomba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-5775","authenticated-orcid":false,"given":"Saul","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"S1047951121002638_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(91)91214-G"},{"key":"S1047951121002638_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01187-2"},{"key":"S1047951121002638_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00878552"},{"key":"S1047951121002638_ref4","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198808000-00146"},{"key":"S1047951121002638_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271001"},{"key":"S1047951121002638_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1782"},{"key":"S1047951121002638_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-6-15"},{"key":"S1047951121002638_ref1","first-page":"198","article-title":"Right ventricular diastolic dysfunction in the postoperative period of tetralogy of Fallot","author":"Cardoso","year":"2003","journal-title":"Arq Bras Cardiol"},{"key":"S1047951121002638_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.033"},{"key":"S1047951121002638_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)40209-2"},{"key":"S1047951121002638_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00532-0"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951121002638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T07:51:23Z","timestamp":1665388283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951121002638\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1047951121002638"],"URL":"https:\/\/doi.org\/10.1017\/s1047951121002638","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2021,7,8]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}