{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:21:29Z","timestamp":1792300889523,"version":"4.4.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121002985_as1\"><jats:title>Background:<\/jats:title><jats:p>Transcatheter ventricular septal defect closure remains a complex procedure with potential complications like complete heart block and aortic regurgitation. The ideal device design for such intervention is still evolving.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121002985_as2\"><jats:title>Aim:<\/jats:title><jats:p>To assess the safety, efficacy, and short-term outcome of ventricular septal defect closure using LifeTech<jats:sup>TM<\/jats:sup> multifunctional (KONAR-MF<jats:sup>TM<\/jats:sup>) VSD Occluder.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121002985_as3\"><jats:title>Patients and methods:<\/jats:title><jats:p>In a multicenre study, 44 patients with haemodynamically significant, restrictive ventricular septal defects underwent closure with the KONAR-MF<jats:sup>TM<\/jats:sup> device from April, 2019 to March, 2020. Clinical, echocardiographic, and angiographic data were collected and reviewed. Patients were followed up at 1, 3, 6, and 12 months.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121002985_as4\"><jats:title>Results:<\/jats:title><jats:p>The median age and weight were 8 (1.7\u201336) years and 20 (11\u201379) kg. Of 44 patients, 8 (18%) had a high muscular and 36 (82%) had a perimembranous defect, of which 6 had mild prolapse of the right coronary cusp. The median ventricular septal defect size was 8.8 (3.9\u201313.4) mm. A retrograde approach was adopted in 39 (88.6%) patients. Nine patients (20.5%) had a small residual leak and there was a slight increase in aortic regurgitation in one patient. One device, which embolised to pulmonary artery was retrieved, and the defect was closed with a larger device. At a median follow-up of 13 (5\u201318) months, the residual leak persisted in 1 (2.3%) patient. Mild aortic regurgitation in one patient remained unchanged. There were no major complications.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121002985_as5\"><jats:title>Conclusion:<\/jats:title><jats:p>Percutaneous closure of ventricular septal defect using KONAR-MF<jats:sup>TM<\/jats:sup> device is safe and effective in short and midterm follow-up including selected patients with perimembranous defect and mild prolapse of the right coronary cusp.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121002985","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T12:18:05Z","timestamp":1627474685000},"page":"755-761","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Percutaneous closure of ventricular septal defect using LifeTech<sup>TM<\/sup> Konar-MF VSD Occluder: initial and short-term multi-institutional 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