{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T05:29:46Z","timestamp":1774157386655,"version":"3.50.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121003449_as1\"><jats:title>Background:<\/jats:title><jats:p>We aimed to characterise the impact of Down syndrome on myocardial performance and loading conditions in infants with Down syndrome and CHD over the peri-operative period by comparing them with infants matched for cardiac lesion with a normal microarray.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003449_as2\"><jats:title>Methods:<\/jats:title><jats:p>Left ventricular global longitudinal strain, right ventricular free wall longitudinal strain, left ventricular end-systolic wall stress, and right ventricular systolic pressure were measured in the two groups over the peri-operative period.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003449_as3\"><jats:title>Results:<\/jats:title><jats:p>Fifty-five infants had a diagnosis of Down syndrome and these were compared with 29 control infants. Left ventricular global longitudinal strain decreased in both groups post-operatively with the Down syndrome group demonstrating some recovery pre-discharge (18 \u00b1 3 versus 16 \u00b1 3 %, p = 0.01). Right ventricular longitudinal strain significantly decreased in both groups post-operatively with the control group demonstrating better recovery by hospital discharge (14 \u00b1 4 versus 18 \u00b1 6 %, p &lt; 0.01). End-systolic wall stress was lower and right ventricular systolic pressure was higher in the Down syndrome group throughout the study period (all p &lt; 0.05). Down syndrome was an independent predictor of the duration of ventilation, post-operative use of inotropes, and intensive care stay. Right ventricular longitudinal strain was an independent predictor of duration of intensive care stay.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003449_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>This study demonstrates the difference between the two groups in relation to left and right ventricular function, particularly prior to discharge, and outlines the additional impact a diagnosis of Down syndrome has on myocardial performance during the peri-operative period.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121003449","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T06:26:41Z","timestamp":1630391201000},"page":"960-968","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Peri-operative myocardial performance in infants with Down syndrome undergoing CHD repair"],"prefix":"10.1017","volume":"32","author":[{"given":"Lyudmyla","family":"Zakharchenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-822X","authenticated-orcid":false,"given":"Afif","family":"EL-Khuffash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor J.","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-8050","authenticated-orcid":false,"given":"Colm","family":"Breatnach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orla","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"S1047951121003449_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.006"},{"key":"S1047951121003449_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2016.04.012"},{"key":"S1047951121003449_ref10","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S27462"},{"key":"S1047951121003449_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.126"},{"key":"S1047951121003449_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90252-1"},{"key":"S1047951121003449_ref18","first-page":"18","article-title":"Evaluation 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