{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:05:57Z","timestamp":1771232757701,"version":"3.50.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chiari network is an infrequently visualized web-like structure in the right atrium that is usually thin and small. Rarely, it can be prominent and elongated with protrusion into the right ventricle during diastole and complications have been reported. Thirty-eight patients (median age 2.5 years) with prolapsing Chiari network were identified and associated cardiac abnormalities documented. Echocardiographic right and left heart parameters were measured and compared to normative data. At presentation, the extent of Chiari network prolapse below the tricuspid annulus was 9.1 \u00b1 3.5 mm (mean \u00b1 standard deviation), mean pulmonary valve annulus diameter z-value was reduced (-0.91 \u00b1 0.64), and mean aortic valve z-value was enlarged (+0.97 \u00b1 0.87). Fourteen patients exhibited no other cardiac abnormality. Eight were noted to have atrial septal defects, eight demonstrated supraventricular dysrhythmias, six had mild to moderate tricuspid valve regurgitation, and one patient each had an atrial septal aneurysm, severe pulmonic valve stenosis, small perimembranous ventricular septal defect, bicuspid aortic valve, and mild right upper pulmonary vein stenosis. Fourteen patients (37%) were seen in follow-up from 1 to 8.5 years later (median 3.2 years). During that time, the magnitude of prolapse across the tricuspid valve decreased by up to 7 mm (median 2 mm). Interventions were required in three patients, but many associated cardiac abnormalities resolved spontaneously with growth. Thus, the presence of a prolapsing Chiari network has a substantial risk of associated CHDs. However, the extent of Chiari network prolapse gradually decreases and many related abnormalities resolve during growth.<\/jats:p>","DOI":"10.1017\/s1047951121003668","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T09:29:36Z","timestamp":1631093376000},"page":"1071-1076","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Prominent prolapsing Chiari network: presentation and prognosis in paediatric patients"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-855X","authenticated-orcid":false,"given":"James J.","family":"Joyce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita J.","family":"Ferns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"S1047951121003668_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.03.019"},{"key":"S1047951121003668_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.03.021"},{"key":"S1047951121003668_ref7","first-page":"333","article-title":"Chiari\u2019s network: persistence of the embryonic remnants of the valve of the sinus venosus in the right atrium. 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