{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:57:46Z","timestamp":1780315066474,"version":"3.54.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121003899_as1\"><jats:title>Objective:<\/jats:title><jats:p>Laterality anomalies are almost always associated with severe cardiac anomalies. Demographic properties, type of the procedures, associated anomalies, and early and mid-term prognosis of four types of laterality anomalies were analysed.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003899_as2\"><jats:title>Methods:<\/jats:title><jats:p>A total of 64 consecutive patients with laterality anomalies were enrolled between July 2014 and July 2020. We grouped the patients as situs solitus dextrocardia (SSD) (n = 12; 18.7%); situs inversus (SI) (n = 16; 25%); right atrial isomerism (RAI) (n = 29; 45.3%); and left atrial isomerism (LAI) (n = 7; 10.9%). TAPVC was only present in the RAI group (31%). Incidence of mitral or tricuspid atresia was higher in the SSD group (25%). All the patients were followed up with a mean of 19.06 \u00b1 17.6 (0.1\u201372) months.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003899_as3\"><jats:title>Results:<\/jats:title><jats:p>Early postoperative mortality was 17 patients, among 107 procedures (15.8%). Twelve patients were in the neonatal period. All ten patients survived after isolated ductal stenting. Fourteen of the deaths were in the RAI group (48.3%). The 3-year survival rates were 85% in LAI, 78.7% in SI, 55.8% in SSD, and 38% in RAI groups. According to the multivariable Cox regression model, mechanical ventilation, kidney injury, RAI, and complex surgery in the neonatal period were independent risk factors for early mortality.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003899_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Laterality anomalies are one of the most challenging patients who commonly had univentricular physiology. The most prevalent anomaly was RAI, and RAI had the worst outcome and survival. Ductal stent is an acceptable first intervention during the neonatal period in suitable patients. Complex procedures may carry a high risk of death in the neonatal period.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121003899","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T07:22:41Z","timestamp":1633072961000},"page":"1129-1135","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of outcomes in patients with abnormal laterality undergoing congenital heart 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