{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:05:38Z","timestamp":1758873938004,"version":"3.40.5"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121003991_as1\"><jats:title>Background:<\/jats:title><jats:p>Paediatric obesity is a worldwide health burden, with growing evidence linking obesity to myocardial function impairments. The study aims to evaluate left ventricular functions among prepubertal obese children to obesity-related clinical and metabolic parameters.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003991_as2\"><jats:title>Methods:<\/jats:title><jats:p>Between June 2019 and March 2020, 40 prepubertal children with obesity were recruited and compared to 40 healthy controls. Patients were assessed for body mass index z scores, waist circumference, body adiposity by bioimpedance analysis, and obesity-related laboratory tests, for example, serum chemerin. Left ventricular functions were assessed using variable echocardiographic modalities, such as M-mode, tissue Doppler, and two-dimensional speckle tracking.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003991_as3\"><jats:title>Results:<\/jats:title><jats:p>Mean patients\u2019 age was 9.25 \u00b1 1.05 years. Left ventricular mass index, E\/E\u2019, and myocardial performance index were significantly increased in obese children than controls. Although M-mode-derived ejection fraction was comparable in both groups, two-dimensional speckle tracking-derived ejection fraction, global longitudinal strain, and global circumferential strain were significantly lower in cases than controls. Left ventricular mass index displayed a positive correlation with body mass index z score (p = 0.003), fat mass index (p = 0.037), and trunk fat mass (p = 0.021). Global longitudinal strain was negatively correlated with body mass index z score (p = 0.015) and fat mass index (p = 0.016). Serum chemerin was positively correlated with myocardial performance index (p = 0.01).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121003991_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Alterations of left ventricular myocardial functions in prepubertal obese children could be detected using different echocardiographic modalities. Chemerin, body mass index z score, fat mass index, and trunk fat mass were correlated with subclinical left ventricular myocardial dysfunction parameters before puberty. Our results reinforce early and strict management of childhood obesity upon detection of changes in anthropometric and body adiposity indices.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121003991","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T09:35:02Z","timestamp":1632908102000},"page":"1246-1253","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["The relevance of left ventricular functions to clinical and metabolic characteristics of prepubertal children with obesity"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9115-910X","authenticated-orcid":false,"given":"Shaimaa","family":"Rakha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanees","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abdel Khalek 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