{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:10:59Z","timestamp":1789006259468,"version":"build-2803163510"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121004091_as1\"><jats:title>Introduction:<\/jats:title><jats:p>Systemic ventricular end-diastolic pressure is an important haemodynamic variable in adult patients with Fontan circulation. Risk factors associated with elevated end-diastolic pressure have not been clearly identified in this population.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121004091_as2\"><jats:title>Methods:<\/jats:title><jats:p>All patients &gt; 18 years with Fontan circulation who underwent cardiac catheterisation at our centre between 1\/08 and 3\/19 were included. Relevant patient variables were extracted. Univariate and multivariate general linear models were analysed to identify variables associated with end-diastolic pressure.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121004091_as3\"><jats:title>Results:<\/jats:title><jats:p>Forty-two patients were included. Median age was 24.0 years (20.9\u201329.0) with a body mass index of 23.7 kg\/m<jats:sup>2<\/jats:sup> (21.5\u201329.7). 10 (23.8%) patients had a systemic right ventricle. The median (Interquartile range) and mean pulmonary artery pressure were 11.0 mmHg (9.0\u201312.0) and 16.0 mmHg (13.0\u201318.0), respectively. On univariate analysis, end-diastolic pressure was positively associated with body mass index (p &lt; 0.01), age &gt; 25 years (p = 0.04), symptoms of heart failure (p &lt; 0.01), systemic ventricular systolic pressure (p = 0.03), pulmonary artery mean pressure (p &lt; 0.01), and taking diuretics (p &lt; 0.01) or sildenafil (p &lt; 0.01). End-diastolic pressure was negatively associated with aortic saturation (p &lt; 0.01). On multivariate analysis, end-diastolic pressure was positively associated with age \u2265 25 years (p &lt; 0.01), and body mass index (p = 0.04).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121004091_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>In a cohort of adult patients with Fontan circulation undergoing catheterisation, end-diastolic pressure was positively associated with age \u2265 25 years and body mass index on multivariate analysis. Maintaining a healthy body mass index may offer haemodynamic benefit in adults with Fontan physiology.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121004091","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T10:06:13Z","timestamp":1633601173000},"page":"1296-1301","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Body mass index and age are associated with ventricular end-diastolic pressure in adults with a Fontan circulation"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-3754","authenticated-orcid":false,"given":"Mary","family":"Howell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Alegria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Paolillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-6165","authenticated-orcid":false,"given":"Matthew C.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"S1047951121004091_ref8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018345"},{"key":"S1047951121004091_ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.68"},{"key":"S1047951121004091_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.5459"},{"key":"S1047951121004091_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1757-8"},{"key":"S1047951121004091_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.06.067"},{"key":"S1047951121004091_ref13","first-page":"1","article-title":"Identification of patient variables that are associated with ventricular end-diastolic pressure before the bidirectional Glenn operation","author":"Schwartz","year":"2021","journal-title":"Cardiol Young"},{"key":"S1047951121004091_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12345"},{"key":"S1047951121004091_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/2150135117752122"},{"key":"S1047951121004091_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.002026"},{"key":"S1047951121004091_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28340"},{"key":"S1047951121004091_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1365"},{"key":"S1047951121004091_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307467"},{"key":"S1047951121004091_ref3","volume-title":"Regression Modeling","author":"Harrell","year":"2016"},{"key":"S1047951121004091_ref6","first-page":"241","article-title":"The impact of aging on left ventricular longitudinal function in healthy subjects: a pulsed tissue Doppler study","volume":"9","author":"Innelli","year":"2008","journal-title":"Eur J Echocardiogr"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951121004091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T08:41:58Z","timestamp":1660639318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951121004091\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,7]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1047951121004091"],"URL":"https:\/\/doi.org\/10.1017\/s1047951121004091","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}