{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:33:49Z","timestamp":1776684829346,"version":"3.51.2"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121004728_as1\"><jats:title>Background:<\/jats:title><jats:p>Ceraflex septal occluder and the Figulla atrial septal defect occluder have the advantage of a pivoting mechanism and softer device architecture. This study sought to examine the safety and efficacy of these occluders compared to the Amplatzer septal occluder.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121004728_as2\"><jats:title>Methods:<\/jats:title><jats:p>This was a retrospective study. Between January, 2013 and April, 2020, patients with at least 6 months of follow-up were included. Early and late-onset outcomes were examined.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121004728_as3\"><jats:title>Results:<\/jats:title><jats:p>Four hundred seven patients (range: 0.17\u201370.72 years; 53.1% &gt;18 years; male: 29.2%) underwent atrial septal defect occlusion using Amplatzer septal occluder (n = 313), Ceraflex septal occluder (n = 36) and FSO (n = 58). A longer procedure time was observed in the Amplatzer septal occluder group. Early-onset complication rates in Amplatzer septal occluder, Ceraflex septal occluder and Figulla atrial septal defect occluder were 3.83%, 5.56% and 0%. Ten (2.46%) patients developed delayed complications (2.56%, 0% and 1.72% in the Amplatzer septal occluder, Ceraflex septal occluder and Figulla atrial septal defect occluder groups). Device erosion rate was not different between groups. The occlusion rates were comparable among all the devices.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121004728_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>There is no significant difference in safety and efficacies between the novel atrial septal defect occluding devices compared to Amplatzer septal occluder.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121004728","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T03:58:56Z","timestamp":1648180736000},"page":"1621-1627","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["The Ceraflex and Figulla atrial septal occluders: early and intermediate-term safety and efficacy study"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-8060","authenticated-orcid":false,"given":"Ming Chern","family":"Leong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-9504","authenticated-orcid":false,"given":"Boekhren","family":"Karyostyko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Nor Hisham","family":"Ramli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-5589","authenticated-orcid":false,"given":"Jason Weng Yew","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazeni","family":"Alwi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"S1047951121004728_ref14","doi-asserted-by":"crossref","first-page":"6090612","DOI":"10.1155\/2020\/6090612","article-title":"Clinical significance of septal malalignment for transcatheter closure of atrial septal defect","volume":"2020","author":"Takaya","year":"2020","journal-title":"J Interv Cardiol"},{"key":"S1047951121004728_ref12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ccd.20211","article-title":"Erosion of Amplatzer septal occluder device after closure of secundum atrial septal defect: review of registry of complications and recommendations to minimize future risk","volume":"63","author":"Amin","year":"2004","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951121004728_ref20","doi-asserted-by":"crossref","first-page":"641742","DOI":"10.3389\/fped.2021.641742","article-title":"Preliminary experience with the New Amplatzer\u2122 Trevisio\u2122 delivery system in transcatheter atrial septal defect closures in children","volume":"9","author":"Haddad","year":"2021","journal-title":"Front Pediatr"},{"key":"S1047951121004728_ref6","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/pace.14049","article-title":"Left atrial appendage and atrial septal occlusion in elderly patients with atrial septal defect and atrial fibrillation","volume":"43","author":"Leong","year":"2020","journal-title":"Pacing Clin Electrophysiol"},{"key":"S1047951121004728_ref11","doi-asserted-by":"crossref","first-page":"E592","DOI":"10.1002\/ccd.24755","article-title":"Very late erosion of Amplatzer septal occluder device presenting as pericardial pain and effusion 8 years after placement","volume":"82","author":"Roberts","year":"2013","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951121004728_ref10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jtcvs.2011.03.006","article-title":"Late erosion of an Amplatzer septal occluder device 6 years after placement","volume":"142","author":"Taggart","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S1047951121004728_ref17","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/joic.12550","article-title":"A novel totally biodegradable device for effective atrial septal defect closure: a 2-year study in sheep","volume":"31","author":"Lu","year":"2018","journal-title":"J Interv Cardiol"},{"key":"S1047951121004728_ref15","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/ccd.28367","article-title":"Pericardial tamponade due to erosion of a Figulla Flex II device after closure of an atrial septal defect","volume":"94","author":"Abe","year":"2019","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951121004728_ref9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.acvd.2014.09.005","article-title":"Transcatheter closure of atrial septal defect with the Figulla(\u00ae) ASD Occluder: a comparative study with the Amplatzer(\u00ae) Septal Occluder","volume":"108","author":"Godart","year":"2015","journal-title":"Arch Cardiovasc Dis"},{"key":"S1047951121004728_ref1","first-page":"383","article-title":"Nonoperative closure of atrial septal defects","volume":"75","author":"King","year":"1974","journal-title":"Surgery"},{"key":"S1047951121004728_ref7","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/978-1-4471-4619-3_72","volume-title":"Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care","author":"Alwi","year":"2014"},{"key":"S1047951121004728_ref8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1540-8183.2009.00497.x","article-title":"Figulla ASD occluder versus Amplatzer Septal Occluder: a comparative study on validation of a novel device for percutaneous closure of atrial septal defects","volume":"22","author":"Pac","year":"2009","journal-title":"J Interv Cardiol"},{"key":"S1047951121004728_ref4","first-page":"e19","article-title":"Early to mid-term follow-up outcomes of percutaneous closure of atrial septal defects using recent generation devices: a single-center experience","volume":"49","author":"Kim","year":"2019","journal-title":"Korean Circ J"},{"key":"S1047951121004728_ref19","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4244\/EIJ-D-17-00006","article-title":"Carag bioresorbable septal occluder (CBSO): histopathology of experimental implants","volume":"13","author":"Sigler","year":"2018","journal-title":"EuroIntervention"},{"key":"S1047951121004728_ref16","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jcin.2019.03.005","article-title":"Cardiac erosions after transcatheter atrial septal defect closure with the Occlutech Figulla Flex device","volume":"12","author":"Auriau","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"S1047951121004728_ref5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00059-014-4192-0","article-title":"Ceraflex versus Amplatzer occluder for secundum atrial septal defect closure. Multicenter clinical experience","volume":"40","author":"Astarcioglu","year":"2015","journal-title":"Herz"},{"key":"S1047951121004728_ref3","first-page":"229","article-title":"A comparison of the in vivo neoendothelialization and wound healing processes of three atrial septal defect occluders used during childhood in a nonrandomized prospective trial","volume":"18","author":"Sahin","year":"2017","journal-title":"Anatol J Cardiol"},{"key":"S1047951121004728_ref13","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1161\/CIRCULATIONAHA.115.019987","article-title":"Relative risk factors for cardiac erosion following transcatheter closure of atrial septal defects: a case-control study","volume":"133","author":"McElhinney","year":"2016","journal-title":"Circulation"},{"key":"S1047951121004728_ref18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ccd.28529","article-title":"Initial experiences with a novel biodegradable device for percutaneous closure of atrial septal defects: from preclinical study to first-in-human experience","volume":"95","author":"Li","year":"2020","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951121004728_ref2","doi-asserted-by":"crossref","first-page":"S2909","DOI":"10.21037\/jtd.2018.02.19","article-title":"Transcatheter closure of atrial septal defect: principles and available devices","volume":"10","author":"Jung","year":"2018","journal-title":"J Thorac Dis"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951121004728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T06:49:41Z","timestamp":1700376581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951121004728\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1047951121004728"],"URL":"https:\/\/doi.org\/10.1017\/s1047951121004728","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,24]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}