{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:12:45Z","timestamp":1776280365497,"version":"3.50.1"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951121005175_as1\"><jats:title>Background:<\/jats:title><jats:p>Growing evidence has emphasised the importance of ventricular performance in functionally single-ventricle patients, particularly concerning diastolic function. Cardiac MRI has been proposed as non-invasive alternative to pre-Fontan cardiac catheterisation in selected patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121005175_as2\"><jats:title>Aim of the study:<\/jats:title><jats:p>To identify clinical and cardiac magnetic resonance predictors of high pre-Fontan end-diastolic ventricular pressure.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121005175_as3\"><jats:title>Method:<\/jats:title><jats:p>In a retrospective single-centre study, 38 patients with functionally univentricular heart candidate for Fontan intervention, who underwent pre-Fontan cardiac catheterisation, beside a comprehensive cardiac MRI, echocardiographic, and clinical assessment were included. Medical and surgical history, cardiac magnetic resonance, cardiac catheterisation, echocardiographic, and clinical data were recorded. We investigated the association between non-invasive parameters and cardiac catheterisation pre-Fontan risk factors, in particular with end-diastolic ventricular pressure. Moreover, the impact of conventional invasive pre-Fontan risk factor on post-operative outcome as also assessed.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121005175_as4\"><jats:title>Results:<\/jats:title><jats:p>Post-operative complications were associated with higher end-diastolic ventricular pressure and Mayo Clinic indexes (p &lt; 0.01 and p = 0.05, respectively). At receiver operating characteristic curve analysis end-diastolic ventricular pressure \u2265 10.5 mmHg predicted post-operative complications with a sensitivity of 75% and specificity of 88% (AUC: 0.795, 95% CI 0.576;1.000, p &lt; 0.05). At multivariate analysis, both systemic right ventricle (OR: 23.312, 95% CI: 2.704\u2013200.979, p &lt; 0.01) and superior caval vein indexed flow (OR: 0.996, 95% CI: 0.993\u20130.999, p &lt; 0.05) influenced end-diastolic ventricular pressure \u2265 10.5 mmHg.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951121005175_as5\"><jats:title>Conclusions:<\/jats:title><jats:p>A reduced superior caval vein flow, evaluated at cardiac magnetic resonance, is associated with higher end-diastolic ventricular pressure a predictor of early adverse outcome in post-Fontan patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951121005175","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T05:31:37Z","timestamp":1640669497000},"page":"1930-1937","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Role of cardiac MRI in the prediction of pre-Fontan end-diastolic ventricular 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