{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:56:32Z","timestamp":1787496992531,"version":"build-2736575974"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951122000415_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the safety, tolerability, and efficacy of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122000415_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study included clinical data from five children and six young adults with pulmonary arterial hypertension receiving selexipag as add-on therapy or as a transition from beraprost sodium or epoprostenol infusion therapy. Clinical efficacy was evaluated by measuring improvement in clinical variables from baseline, including hemodynamic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122000415_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 11 patients, 6 were switched from beraprost sodium to selexipag and one paediatric patient transitioned from epoprostenol to selexipag. The median maintenance dose of selexipag in children was 80 \u03bcg\/kg\/day. In nine patients undergoing repeat catheterisation, statistically significant improvements were observed after the initiation of selexipag in terms of mean pulmonary arterial pressure (p &lt; 0.01), pulmonary vascular resistance index (p &lt; 0.05), and cardiac index (p &lt; 0.01). None of the patients had clinical worsening after selexipag during follow-up, but one young adult patient discontinued treatment due to severe headache. The most common side effect profiles were headache, nausea, abdominal pain, jaw pain, myalgia, and diarrhoea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122000415_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Selexipag may have a favourable safety profile and potential efficacy in children and young adults with pulmonary arterial hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951122000415","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T05:25:06Z","timestamp":1649222706000},"page":"196-200","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Clinical efficacy and safety of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5875-4628","authenticated-orcid":false,"given":"Shinichi","family":"Takatsuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaka","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurika","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"S1047951122000415_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199311000-00007"},{"key":"S1047951122000415_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-017-0262-z"},{"key":"S1047951122000415_ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000367630"},{"key":"S1047951122000415_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1677-7"},{"key":"S1047951122000415_ref5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00137511"},{"key":"S1047951122000415_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/2045894019876545"},{"key":"S1047951122000415_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.03.029"},{"key":"S1047951122000415_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/2045893217703369"},{"key":"S1047951122000415_ref14","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.197152"},{"key":"S1047951122000415_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.575"},{"key":"S1047951122000415_ref13","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.138305"},{"key":"S1047951122000415_ref2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.9804054"},{"key":"S1047951122000415_ref3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0011OC"},{"key":"S1047951122000415_ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503184"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122000415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:48:13Z","timestamp":1684475293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122000415\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S1047951122000415"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122000415","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}