{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:00:11Z","timestamp":1791284411548,"version":"4.1.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122000580_as1\"><jats:title>Background and objectives:<\/jats:title><jats:p>There is sparse literature on cardiac arrhythmias and the utility of ambulatory rhythm monitoring in patients with postural tachycardia syndrome and orthostatic intolerance. This study\u2019s primary aim was to investigate the prevalence of arrhythmias in this population. Knowing the prevalence and types of arrhythmias in dysautonomia patients could influence the decision to pursue ambulatory rhythm monitoring and ultimately guide therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122000580_as2\"><jats:title>Methods:<\/jats:title><jats:p>This retrospective descriptive study examined the frequency of cardiac arrhythmias, as detected by ambulatory rhythm monitoring, in children with postural tachycardia syndrome\/orthostatic intolerance or syncope who were seen at the Children\u2019s National Hospital Electrophysiology Clinic between January 2001 and December 2020.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122000580_as3\"><jats:title>Results:<\/jats:title><jats:p>In postural tachycardia syndrome\/orthostatic intolerance patients, arrhythmia was detected on 15% of 332 ambulatory rhythm monitors. In syncope patients, arrhythmia was detected on 16% of 157 ambulatory rhythm monitors, not significantly different from the postural tachycardia syndrome\/orthostatic intolerance group. The difference in rate of arrhythmia detection between 24-hour Holter and 2-week Zio\u00ae monitoring was not statistically significant.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122000580_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>This study suggests that a substantial proportion of postural tachycardia syndrome\/orthostatic intolerance patients may have concomitant underlying cardiac arrhythmias, at a frequency similar to what is seen in patients undergoing primary evaluation for cardiac symptoms such as chest pain, palpitations, and syncope. In the appropriate clinical context, physicians caring for postural tachycardia syndrome\/orthostatic intolerance patients should consider additional evaluation for arrhythmias beyond sinus tachycardia.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122000580","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T08:53:33Z","timestamp":1646643213000},"page":"255-259","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Cardiac arrhythmias in postural tachycardia syndrome and orthostatic intolerance"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-3579","authenticated-orcid":false,"given":"Jeff","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Litt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2488-6056","authenticated-orcid":false,"given":"Jeffrey P.","family":"Moak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"S1047951122000580_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02079464"},{"key":"S1047951122000580_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.12.014"},{"key":"S1047951122000580_ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1673"},{"key":"S1047951122000580_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.44.3.304"},{"key":"S1047951122000580_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.11.028"},{"key":"S1047951122000580_ref15","first-page":"204","article-title":"The value of Holter monitoring in the assessment of pediatric patients","volume":"7","author":"Hegazy","year":"2007","journal-title":"Indian Pacing Electrophysiol J"},{"key":"S1047951122000580_ref2","first-page":"S19","article-title":"Postural tachycardia syndrome (POTS)","volume":"45","author":"Low","year":"1995","journal-title":"Neurology"},{"key":"S1047951122000580_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113625"},{"key":"S1047951122000580_ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000084590"},{"key":"S1047951122000580_ref16","first-page":"975","article-title":"Yield of 48-hour Holter monitoring in children with unexplained palpitations and significance of associated symptoms","volume":"67","author":"Aman","year":"2017","journal-title":"J Pak Med Assoc"},{"key":"S1047951122000580_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.144501"},{"key":"S1047951122000580_ref9","first-page":"149","article-title":"Electrographic patch devices and contemporary wireless cardiac monitoring","volume":"6","author":"Fung","year":"2015","journal-title":"Front Pediatr"},{"key":"S1047951122000580_ref14","first-page":"235","article-title":"Diagnostic usefulness of Holter monitoring in pediatric fainting and syncope","volume":"41","author":"Drago","year":"1989","journal-title":"Minerva Pediatr"},{"key":"S1047951122000580_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02089-0"},{"key":"S1047951122000580_ref21","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1610370"},{"key":"S1047951122000580_ref22","doi-asserted-by":"publisher","DOI":"10.19102\/icrm.2021.120201"},{"key":"S1047951122000580_ref20","first-page":"286","article-title":"Analysis of 2017 Holter records in pediatric patients","volume":"42","author":"Ayabakan","year":"2000","journal-title":"Turk J 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2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}