{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:28:49Z","timestamp":1771658929951,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122000828_as1\"><jats:title>Objectives:<\/jats:title><jats:p>We aim to describe the early and upto 16 months follow-up of post-coronavirus disease (COVID), multi-system inflammatory syndrome in children (MIS-C), with special reference to cardiac involvement.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122000828_as2\"><jats:title>Study design:<\/jats:title><jats:p>This cohort non-interventional descriptive study included patients &lt;18 years admitted between May, 2020 and April, 2021. Based on underlying similarities, children were classified as post-COVID MIS-C with overlapping Kawasaki Disease, MIS-C with no overlapping Kawasaki Disease, and MIS-C with shock. Post-discharge, patients were followed at 1, 3, 6, 12, and 16 months.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122000828_as3\"><jats:title>Results:<\/jats:title><jats:p>Forty-one patients predominantly males (73%), at median age of 7 years (range 0.2\u201316 years) fulfilled the World Health Organisation criteria for MIS-C. Cardiac involvement was seen in 15 (36.5%); impaired left ventricle (LV) function in 5 (12.2%), coronary artery involvement in 10 (24.4%), pericardial effusion in 6 (14.6%) patients, and no arrhythmias. There were two hospital deaths (4.9%), both in MIS-C shock subgroup (2\/10, 20%). At 1 month, there was persistent LV dysfunction in 2\/5, coronary artery abnormalities in 7\/10, and pericardial effusion resolved completely in all patients. By 6 months, LV function returned to normal in all but coronary abnormalities persisted in two patients. At last follow-up (median 9.8 months, interquartile range 2\u201316 months), in 36\/38 (94.7%) patients, coronary artery dilatation was persistent in 2 (20%) patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122000828_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Children with MIS-C have a good early outcome, though MIS-C with shock can be life-threatening subgroup in a resource-constrained country setting. On midterm follow-up, there is normalisation of LV function in all and recovery of coronary abnormalities in 80% of patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122000828","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T03:58:24Z","timestamp":1648180704000},"page":"371-379","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["Short to midterm follow-up of multi-system inflammatory syndrome in children with special reference to cardiac involvement"],"prefix":"10.1017","volume":"33","author":[{"given":"Omeir A.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-0240","authenticated-orcid":false,"given":"Masood","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad 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