{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:44:05Z","timestamp":1787507045873,"version":"build-2736575974"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S104795112200110X_as1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary objective was to evaluate the trend of blood sirolimus concentrations in neonates following ductal stenting. The long-term outcomes and incidence of infections were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112200110X_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective open-label observational study in a tertiary referral centre over a 1-year period. Serum sirolimus levels were estimated at 1 hour and 24hrs post-stent insertion followed by 7 days in neonates who underwent ductal stenting. The trend in sirolimus levels, incidence of infections, complications and outcomes following ductal stenting were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112200110X_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seven neonates with duct-dependent pulmonary circulation underwent ductal stenting at median age of 8.5 days and weight of 2.83kg. The average stent size was 3.5\u00b10.4 mm, and average stent length was 16.3\u00b15.1 mm. The mean sirolimus concentrations at 1 hour, 24 hours and 7 days were 41.3\u00b16.9ng\/ml, 15.4\u00b17.1ng\/ml and 3.1\u00b10.85ng\/ml respectively. Levels fell below therapeutic range for all patients by 7 days. Three patients had sepsis or necrotising enterocolitis, but responded well to antibiotics; 1 patient had aspiration related sudden death. There were no further events at a mean follow-up of 207 days, and 4 patients underwent elective surgery at 238 \u00b1 81 days after ductal stenting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S104795112200110X_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrates applicability of drug-eluting stents for ductal stenting in newborns. Drug-eluting stents with abluminal drug delivery are associated with high sirolimus levels in initial hours but rapidly taper to negligible levels within a week of implantation. Neonates with high pre-procedure likelihood of infection developed sepsis but responded well to conservative management. The patency of drug-eluting ductal stents is preserved over long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s104795112200110x","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T23:11:48Z","timestamp":1651705908000},"page":"437-443","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Safety of drug-eluting stents for stenting patent arterial duct in neonates"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-7531","authenticated-orcid":false,"given":"Harikrishnan K.N.","family":"Kurup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-8076","authenticated-orcid":false,"given":"Arun","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-0759","authenticated-orcid":false,"given":"Deepa","family":"Sasikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-6396","authenticated-orcid":false,"given":"Kavassery M.","family":"Krishnamoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"S104795112200110X_ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028972"},{"key":"S104795112200110X_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-020-02381-4"},{"key":"S104795112200110X_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.066"},{"key":"S104795112200110X_ref4","article-title":"Duct stenting versus modified Blalock-Taussig shunt in neonates and infants with duct-dependent pulmonary blood flow: A systematic review and meta-analysis","author":"Alsagheir","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S104795112200110X_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.06.014"},{"key":"S104795112200110X_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.06.028"},{"key":"S104795112200110X_ref8","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.41054"},{"key":"S104795112200110X_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002233"},{"key":"S104795112200110X_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1077-6"},{"key":"S104795112200110X_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv435"},{"key":"S104795112200110X_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-017-5864-0"},{"key":"S104795112200110X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.04.007"},{"key":"S104795112200110X_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029987"},{"key":"S104795112200110X_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2017.1318057"},{"key":"S104795112200110X_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00211-2"},{"key":"S104795112200110X_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-015-0059-6"},{"key":"S104795112200110X_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s43044-020-00084-y"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795112200110X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T03:22:11Z","timestamp":1678850531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795112200110X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S104795112200110X"],"URL":"https:\/\/doi.org\/10.1017\/s104795112200110x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. 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