{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:08:29Z","timestamp":1776308909007,"version":"3.50.1"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122001512_as1\"><jats:title>Background:<\/jats:title><jats:p>Neonatal enteroviral myocarditis is a rare but potentially fatal illness. We sought to identify echocardiographic markers at diagnosis that could help risk-stratify infants for poor outcome and to characterise late sequelae.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122001512_as2\"><jats:title>Methods:<\/jats:title><jats:p>We reviewed data for infants &lt;30 days of age diagnosed with enteroviral myocarditis between 1999 and 2019 at Children\u2019s Wisconsin. Echo measures were collected retrospectively from the initial neonatal study including left ventricular ejection fraction, shortening fraction, diastolic and systolic dimensions, and peak global circumferential and longitudinal strain.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122001512_as3\"><jats:title>Results:<\/jats:title><jats:p>Fourteen neonates were diagnosed at an average age of 11 days. All had abnormal left ventricular ejection fraction (mean 38%; range 22\u201353%) at diagnosis. Three infants died, and one required transplantation during initial hospital. The 10 transplant-free survivors had significantly better global circumferential strain and global longitudinal strain at the initial echo compared to the 4 who died or needed transplant (global circumferential strain \u221213.2% versus \u22126.8%, p = 0.005; global longitudinal strain \u22128.8% versus \u22124.7%, p = 0.016). All other measures of left ventricular systolic function\/dimensions were similar between the two groups. Follow-up data were available for 8\/10 survivors; 5\/8 had a persistently abnormal echo at an average interval of 8.3 years. 4\/8 developed a left ventricular aneurysm that was consistently localised to the posterior basal wall.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122001512_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Neonatal enteroviral myocarditis carries a high risk of early mortality and late morbidity. Echo-derived left ventricular strain measures have utility in risk stratifying infants with enteroviral myocarditis. Most survivors continue to have late dysfunction necessitating cardiology surveillance and medical therapy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122001512","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T09:21:34Z","timestamp":1652865694000},"page":"704-709","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic utility of echocardiographically derived left ventricular strain in assessing neonatal enteroviral myocarditis outcome"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2327-7574","authenticated-orcid":false,"given":"Hugh F.","family":"Bigg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Kindel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Frommelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"S1047951122001512_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12248"},{"key":"S1047951122001512_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(90)90200-O"},{"key":"S1047951122001512_ref6","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200406010-00001"},{"key":"S1047951122001512_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12787"},{"key":"S1047951122001512_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s002460010214"},{"key":"S1047951122001512_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.165183"},{"key":"S1047951122001512_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu184"},{"key":"S1047951122001512_ref9","first-page":"2324709617729393","article-title":"Neonatal enteroviral myocarditis with severe dystrophic calcification: novel treatment with pocapavir","volume":"5","author":"Wittekind","year":"2017","journal-title":"J Invest Med High Impact Case Rep"},{"key":"S1047951122001512_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00964.x"},{"key":"S1047951122001512_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2003.10.007"},{"key":"S1047951122001512_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80944-0"},{"key":"S1047951122001512_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.04.004"},{"key":"S1047951122001512_ref20","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001001"},{"key":"S1047951122001512_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.01.015"},{"key":"S1047951122001512_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034439"},{"key":"S1047951122001512_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181e8b44b"},{"key":"S1047951122001512_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2019.08.018"},{"key":"S1047951122001512_ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.902833"},{"key":"S1047951122001512_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.008"},{"key":"S1047951122001512_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.01.015"},{"key":"S1047951122001512_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-224133"},{"key":"S1047951122001512_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.01.021"},{"key":"S1047951122001512_ref12","first-page":"2751","article-title":"Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy","volume":"63","author":"Thavendiranathan","year":"2014","journal-title":"J Am Soc Echocardiog"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122001512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T08:48:25Z","timestamp":1706172505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122001512\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,18]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1047951122001512"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122001512","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,18]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. 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