{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:48:25Z","timestamp":1756309705065,"version":"3.40.5"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122001524_as1\"><jats:title>Introduction and background:<\/jats:title><jats:p>Mortality between stages 1 and 2 single-ventricle palliation is significant. Home-monitoring programmes are suggested to reduce mortality. Outcomes and risk factors for adverse outcomes for European programmes have not been published.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122001524_as2\"><jats:title>Aims:<\/jats:title><jats:p>To evaluate the performance of a home-monitoring programme at a medium-sized United Kingdom centre with regards survival and compare performance with other home-monitoring programmes in the literature.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122001524_as3\"><jats:title>Methods:<\/jats:title><jats:p>All fetal and postnatal diagnosis of a single ventricle were investigated with in-depth analysis of those undergoing stage 1 palliation and entered the home-monitoring programme between 2016 and 2020. The primary outcome was survival. Secondary outcomes included multiple parameters as potential predictors of death or adverse outcome.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122001524_as4\"><jats:title>Results:<\/jats:title><jats:p>Of 217 fetal single-ventricle diagnoses during the period 2016\u20132020, 50.2% progressed to live birth, 35.4% to stage 1 and 29.5% to stage 2. Seventy-four patients (including 10 with postnatal diagnosis) entered the home-monitoring programme with six deaths making home-monitoring programme mortality 8.1%. Risk factors for death were the hybrid procedure as the only primary procedure (OR 33.0, p &lt; 0.01), impaired cardiac function (OR 10.3, p &lt; 0.025), Asian ethnicity (OR 9.3, p &lt; 0.025), lower mean birth-weight (2.69 kg versus 3.31 kg, p &lt; 0.01), and lower mean weight centiles during interstage follow-up (mean centiles of 3.1 versus 10.8, p &lt; 0.01)<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122001524_as5\"><jats:title>Conclusion:<\/jats:title><jats:p>Survival in the home-monitoring programme is comparable with other home-monitoring programmes in the literature. Hybrid procedure, cardiac dysfunction, sub-optimal weight gain, and Asian ethnicity were significant risk factors for death. Home-monitoring programmes should continue to raise awareness of these factors and seek solutions to mitigate adverse events. Future work to generalise home-monitoring programme and single-ventricle fetus to stage 2 outcomes in the United Kingdom will require multi-centre collaboration.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122001524","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T11:36:57Z","timestamp":1652701017000},"page":"710-717","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Performance of a single-ventricle home-monitoring programme: survival and predictors of adverse outcome"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-4787","authenticated-orcid":false,"given":"Peter 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