{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:34:40Z","timestamp":1767598480182,"version":"3.40.5"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122002220_as1\"><jats:title>Background:<\/jats:title><jats:p>This study aimed to evaluate electrocardiographic and echocardiographic findings, Holter recordings of the multisystem inflammatory syndrome in children, and to identify prognostic factors for cardiac involvement.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002220_as2\"><jats:title>Methods:<\/jats:title><jats:p>We retrospectively reviewed demographic characteristics, medical data, laboratory findings, electrocardiogram and echocardiographic findings, 24-hour Holter recordings, need for an ICU, and extracorporeal membrane oxygenation in multisystem inflammatory syndrome in children. Acute left ventricular systolic dysfunction was defined as left ventricular ejection fraction (EF)\u00a0\u2264%55 on echocardiography.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002220_as3\"><jats:title>Results:<\/jats:title><jats:p>Sixty-seven children were included in the study. 24-hour Holters were recorded in 61.2% of the patients and 49.2% were normal. On echocardiographic examination, 14.9% of the patients had systolic dysfunction (EF \u2264 55%). While 32.8% of patients had mild mitral regurgitation, 3% had moderate mitral regurgitation, and 6% had mild aortic regurgitation. There was no statistically significant difference in EF values between the group with arrhythmia in Holter and the group with normal Holter results (p \u2265 0.05). B-type natriuretic peptide was positively correlated with C-reactive protein, ferritin, and fibrinogen. Significant effectivity of the B-type natriuretic peptide value was observed in the differentiation of those with EF \u2264 and &gt; 55%. Extracorporeal membrane oxygenation support was needed for three (4.5%) patients. One patient who died had systemic juvenile idiopathic arthritis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002220_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Neutrophil\/lymphocyte ratio, C-reactive protein, D-dimer, ferritin, troponin, and B-type natriuretic peptide were found to be significantly higher in patients with systolic dysfunction. Also, the cut-off value of 1700 pg\/ml for B-type natriuretic peptide was significantly effective. These parameters may indicate the severity of the disease but should be supported by prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122002220","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T06:45:40Z","timestamp":1657867540000},"page":"1117-1123","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac involvement in multisystem inflammatory syndrome in children: single-centre experience"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5146-0686","authenticated-orcid":false,"given":"Vildan","family":"Atasayan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-5624","authenticated-orcid":false,"given":"\u00d6zge P.","family":"Akbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eeng\u00fcl","family":"\u00c7a\u011flayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"S\u00f6zeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Hasbal Akku\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alican","family":"Vuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-8510","authenticated-orcid":false,"given":"Taliha","family":"\u00d6ner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-2881","authenticated-orcid":false,"given":"Mehmet","family":"Karacan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"S1047951122002220_ref8","unstructured":"8. Centers for Disease Control and Prevention. Emergency preparedness and response: health alert network, May 14, 2020. https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp, Accessed June 16, 2020."},{"key":"S1047951122002220_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30120-1"},{"key":"S1047951122002220_ref29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050065"},{"key":"S1047951122002220_ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03766-6"},{"key":"S1047951122002220_ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0702"},{"key":"S1047951122002220_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"S1047951122002220_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytaa132"},{"key":"S1047951122002220_ref21","first-page":"1","article-title":"Elevated troponin in patients with coronavirus disease 2019: possible mechanisms","volume":"00","author":"Tersalvi","year":"2020","journal-title":"J Card Fail"},{"key":"S1047951122002220_ref15","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202288"},{"key":"S1047951122002220_ref38","first-page":"1010","article-title":"Electrocardiography Holter monitoring in critically ill patients with coronavirus disease 2019 (COVID-19)","volume":"130","author":"Laleh Far","year":"2020","journal-title":"Pol Arch Intern Med"},{"key":"S1047951122002220_ref5","unstructured":"5. World Federation of Pediatric Intensive and Critical Care Societies media release: Expert panel conclusions following the 2 May Pediatric Intensive Care-COVID-19 International Collaborative Conference Call, May 4, 2020, http:\/\/www.wfpiccs.org\/wpcontent\/uploads\/2020\/05\/Media-statement-Final.pdf, Accessed June 22, 2020."},{"key":"S1047951122002220_ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"S1047951122002220_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03357-1"},{"key":"S1047951122002220_ref7","unstructured":"7. Royal College of Paediatrics and Child Health. Guidance: paediatric multisystem inflammatory syndrome temporally associated with COVID-19. https:\/\/www.rcpch.ac.uk\/resources\/guidance-paediFFELatric-multisystem-inflammatory-syndrome-temporallyassociated-covid-19-pims, Accessed June 16, 2020,"},{"key":"S1047951122002220_ref16","first-page":"5","article-title":"Toxic shock-like syndrome and COVID-19: a case report of multisystem inflammatory syndrome in children (MIS-C)","volume":"1207","author":"Greene","year":"2020","journal-title":"Am J Emerg Med"},{"key":"S1047951122002220_ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03332-4"},{"key":"S1047951122002220_ref6","unstructured":"6. World Health Organization. Multisystem inflammatory syndrome in children and adolescents with COVID-19, 15 May 2020. https:\/\/www.who.int\/publications\/i\/item\/multisystem-inflammatory-syndrome-in-children-and-adolescentswith-covid-19, Accessed June 16, 2020,"},{"key":"S1047951122002220_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa145"},{"key":"S1047951122002220_ref41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141113"},{"key":"S1047951122002220_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0950"},{"key":"S1047951122002220_ref22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-1711"},{"key":"S1047951122002220_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa307"},{"key":"S1047951122002220_ref34","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1096"},{"key":"S1047951122002220_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa107"},{"key":"S1047951122002220_ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"S1047951122002220_ref42","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25245"},{"key":"S1047951122002220_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"S1047951122002220_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piaa069"},{"key":"S1047951122002220_ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"S1047951122002220_ref43","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217960"},{"key":"S1047951122002220_ref47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"S1047951122002220_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2005073"},{"key":"S1047951122002220_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2010459"},{"key":"S1047951122002220_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30912-0"},{"key":"S1047951122002220_ref35","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa253"},{"key":"S1047951122002220_ref45","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"S1047951122002220_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"S1047951122002220_ref39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/jrms.JRMS_1195_20","article-title":"Myocardial damage in multisystem inflammatory syndrome associated with COVID\u201019 in children and adolescents","volume":"26","author":"Vukomanovic","year":"2021","journal-title":"J Res Med Sci"},{"key":"S1047951122002220_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2094"},{"key":"S1047951122002220_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0360-5"},{"key":"S1047951122002220_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10374"},{"key":"S1047951122002220_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piaa061"},{"key":"S1047951122002220_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04749-4"},{"key":"S1047951122002220_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa288"},{"key":"S1047951122002220_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.05.058"},{"key":"S1047951122002220_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03699-0"},{"key":"S1047951122002220_ref13","unstructured":"13. CDC. Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). Updated May 20, 2020. Available at: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/daily-life-coping\/children\/mis-c.html, Accessed October 1, 2020."}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122002220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T13:15:01Z","timestamp":1694783701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122002220\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1047951122002220"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122002220","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. 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