{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:04:40Z","timestamp":1781813080513,"version":"3.54.5"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122002414_as1\"><jats:title>Background:<\/jats:title><jats:p>Multi-system inflammatory syndrome in children and Kawasaki disease have overlapping clinical features but comparative echocardiographic studies are lacking.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002414_as2\"><jats:title>Methods:<\/jats:title><jats:p>We reviewed echocardiography findings of all multi-system inflammatory syndrome cases between 1st April and 31st July, 2020 and typical Kawasaki disease patients with coronary arteries abnormalities consecutively followed between 1st October, 2016 and June 30th, 2019.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002414_as3\"><jats:title>Results:<\/jats:title><jats:p>We included 40 multi-system inflammatory syndrome children (25 males, 62.5%) and 45 Kawasaki disease patients (31 males, 68.9%) at a mean age of 6.4\u00a0years old and 8\u00a0years old, respectively. Four out of 40 multi-system inflammatory syndrome children had coronary arteries abnormalities. Left ventricle ejection fraction was normal in both groups. Global longitudinal strain was normal although Kawasaki disease group had significantly lower values (\u201320.0 versus \u201321.7%; p = 0.02). Basal segments were the most affected in Kawasaki disease patients with significant differences in the basal anterior, anterolateral, and anteroseptal strain: \u201318.2 versus \u201323.0% (p = 0.002), \u201316.7 versus \u201322.0% (p &lt; 0.001), \u201316.7 versus \u201319.5% (p = 0.034), respectively. The basal anterolateral and anteroseptal segments in Kawasaki disease patients were the only ones with an absolute reduction of longitudinal strain (\u201316.7% both) consistent with the greater left main coronary involvement in this cohort.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002414_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Our findings are consistent with the transient cardiac involvement in multi-system inflammatory syndrome, as opposed to the subtle and chronic myocardial involvement in Kawasaki disease children with coronary arteries abnormalities. We speculate that the mechanism of cardiac impairment in the few multi-system inflammatory syndrome children with reduced global longitudinal strain is not related to coronary arteries abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122002414","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T06:01:57Z","timestamp":1659506517000},"page":"1177-1183","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Segmental and global longitudinal strain differences between Kawasaki disease and multi-system inflammatory syndrome in 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