{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:59:57Z","timestamp":1747173597581,"version":"3.40.5"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122002591_as1\"><jats:title>Main aim:<\/jats:title><jats:p>To electrophysiologically determine the impact of moderate to severe chronic hypoxia (H) resulting from a wide array of CHD (HCHD) conditions on the integrity of brainstem function.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002591_as2\"><jats:title>Materials and methods:<\/jats:title><jats:p>Applying brainstem auditory-evoked response methodology, 30 chronically afflicted HCHD patients, who already had undergone heart surgery, were compared to 28 healthy control children (1\u201315 yo) matched by age, gender and socioeconomic condition. Blood oxygen saturation was clinically determined and again immediately before brainstem auditory-evoked response testing.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002591_as3\"><jats:title>Results:<\/jats:title><jats:p>Among HCHD children, auditory wave latencies (I, III and V) were significantly longer (medians: I, 2.02 ms; III, 4.12 ms, and; V, 6.30 ms) compared to control (medians: I, 1.67ms; III, 3.72 ms, and; V, 5.65 ms), as well as interpeak intervals (HCHD medians: I-V, 4.25 ms, and; III-V, 2.25ms; control medians: I-V, 3.90 ms and, III-V, 1.80 ms) without significant differences in wave amplitudes between groups. A statistically significant and inverse correlation between average blood oxygen saturation of each group (control, 94%; HCHD, 78%) and their respective wave latencies and interpeak intervals was found.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122002591_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>As determined by brainstem auditory-evoked responses, young HCHD patients manifestly show severely altered neuronal conductivity in the auditory pathway strongly correlated with their hypoxic condition. These observations are strongly supported by different brainstem neurological and image studies showing that alterations, either in microstructure or function, result from the condition of chronic hypoxia in CHD. The non-altered wave amplitudes are indicative of relatively well-preserved neuronal relay nuclei.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122002591","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T10:01:17Z","timestamp":1662372077000},"page":"1569-1573","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Brainstem auditory-evoked responses among children afflicted by severely hypoxic CHD"],"prefix":"10.1017","volume":"33","author":[{"given":"F. Bernardo","family":"Pliego-Rivero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keila","family":"Isaac-Oliv\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-1387","authenticated-orcid":false,"given":"Gloria A.","family":"Otero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"S1047951122002591_ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829bfdcf"},{"key":"S1047951122002591_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.145"},{"key":"S1047951122002591_ref15","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4716"},{"key":"S1047951122002591_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.05.027"},{"key":"S1047951122002591_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951108002977"},{"key":"S1047951122002591_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.09.053"},{"key":"S1047951122002591_ref27","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003606"},{"key":"S1047951122002591_ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"},{"key":"S1047951122002591_ref20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-04-01302.2001"},{"key":"S1047951122002591_ref30","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071461"},{"key":"S1047951122002591_ref33","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.086280"},{"key":"S1047951122002591_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.04.032"},{"key":"S1047951122002591_ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013051"},{"key":"S1047951122002591_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1077-6"},{"key":"S1047951122002591_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811402073"},{"key":"S1047951122002591_ref12","first-page":"605","article-title":"Alteraciones electroencefalogr\u00e1ficas y del neurodesarrollo en ni\u00f1os portadores de cardiopat\u00edas cong\u00e9nitas severas. Estudio preliminar","volume":"149","author":"Esquivel-Hern\u00e1ndez","year":"2013","journal-title":"Gac Med Mex"},{"key":"S1047951122002591_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.09.029"},{"key":"S1047951122002591_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.016"},{"key":"S1047951122002591_ref18","article-title":"Preoperative MRI abnormalities are common in full-term infants with severe CHD and resemble lesions in pre-term infants. Abstracts of the 10th International Child Neurology Congress, June 11\u201316, 2006, Montreal, Canada","volume":"37","author":"Licht","year":"2006","journal-title":"Neuropediatrics"},{"key":"S1047951122002591_ref23","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002073"},{"key":"S1047951122002591_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(12)80328-7"},{"key":"S1047951122002591_ref26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00117.2013"},{"key":"S1047951122002591_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.65"},{"key":"S1047951122002591_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(92)90005-J"},{"key":"S1047951122002591_ref40","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450305"},{"key":"S1047951122002591_ref41","unstructured":"41. WMA. World Medical Association Declaration of Helsinki, \u201cEthical principles for medical research involving human subjects\u201d (2013), available at (https:\/\/www.wma.net\/policies-post\/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects\/)."},{"key":"S1047951122002591_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019881"},{"key":"S1047951122002591_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2018.02.004"},{"key":"S1047951122002591_ref11","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182218622"},{"key":"S1047951122002591_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15932"},{"key":"S1047951122002591_ref13","first-page":"588","article-title":"Electroencephalographic and neurodevelopmental disorders in severe congenital heart disease: A follow-up study","volume":"151","author":"Esquivel-Hern\u00e1ndez","year":"2015","journal-title":"Gac Med Mex"},{"key":"S1047951122002591_ref31","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3260"},{"key":"S1047951122002591_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000178"},{"key":"S1047951122002591_ref38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01142.x"},{"key":"S1047951122002591_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.06.013"},{"key":"S1047951122002591_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(08)60571-4"},{"key":"S1047951122002591_ref32","first-page":"CC01","article-title":"To study brain stem auditory evoked potential in patients with type 2 diabetes mellitus- A cross-sectional comparative study","volume":"10","author":"Sushil","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"S1047951122002591_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.4450"},{"key":"S1047951122002591_ref22","doi-asserted-by":"publisher","DOI":"10.1080\/1086508X.2009.11079735"},{"key":"S1047951122002591_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/nature11314"},{"key":"S1047951122002591_ref37","doi-asserted-by":"publisher","DOI":"10.1038\/nature11007"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122002591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T07:10:57Z","timestamp":1695625857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122002591\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1047951122002591"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122002591","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}