{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:14Z","timestamp":1786999574704,"version":"build-2736575974"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951122002839_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In newborns with hypoxic-ischaemic encephalopathy, more profound altered right and left ventricular function has been associated with mortality or brain injury. Mechanisms underlying cardiac dysfunction in this population are thought to be related to the persistence of increased pulmonary vascular resistance and myocardial ischaemia. We sought to compare cardiac function in newborns with hypoxic-ischaemic encephalopathy to controls using echocardiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122002839_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We did a retrospective case\u2013control study with moderate or severe hypoxic-ischaemic encephalopathy between 2008 and 2017. Conventional and speckle-tracking echocardiography measures were extracted to quantify right and left ventricular systolic and diastolic function. Fifty-five newborns with hypoxic-ischaemic encephalopathy were compared to 28 controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122002839_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Hypoxic-ischaemic encephalopathy newborns had higher estimated systolic pulmonary pressure (62.5 \u00b1 15.0 versus 43.8 \u00b1 17.3 mmHg, p &lt; 0.0001) and higher systolic pulmonary artery pressure\/systolic blood pressure ratio [101 \u00b1 16 (iso-systemic) versus 71 \u00b1 27 (2\/3 systemic range) %, p &lt; 0.0001]. Tricuspid annular plane systolic excursion was decreased (7.5 \u00b1 2.2 versus 9.0 \u00b1 1.4 mm, p = 0.002), E\/e\u2019 increased (7.9 \u00b1 3.3 versus 5.8 \u00b1 2.0, p = 0.01), and right ventricle-myocardial performance index increased (68.1 \u00b1 21.5 versus 47.8 \u00b1 9.5, p = 0.0001) in hypoxic-ischaemic encephalopathy. Conventional markers of left ventricle systolic function were similar, but e\u2019 velocity (0.059 \u00b1 0.019 versus 0.070 \u00b1 0.01, p = 0.03) and left ventricle-myocardial performance index were statistically different (77.9 \u00b1 26.2 versus 57.9 \u00b1 11.2, p = 0.001). The hypoxic-ischaemic encephalopathy group had significantly altered right and left ventricular deformation parameters by speckle-tracking echocardiography. Those with decreased right ventricle-peak longitudinal strain were more likely to have depressed left ventricle-peak longitudinal strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122002839_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Newborns with hypoxic-ischaemic encephalopathy have signs of increased pulmonary pressures and altered biventricular systolic and diastolic function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951122002839","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T04:04:42Z","timestamp":1662437082000},"page":"1587-1596","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Altered biventricular function in neonatal hypoxic-ischaemic encephalopathy: a case\u2013control echocardiographic study"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-0964","authenticated-orcid":false,"given":"Gabriel","family":"Altit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Lomeli","family":"Bonifacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina V.","family":"Guimaraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Chock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisa","family":"Van Meurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Bhombal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"S1047951122002839_ref5","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1164\/rccm.201903-0583OC","article-title":"Impaired right ventricular performance is associated with adverse outcome after hypoxic ischemic encephalopathy","volume":"200","author":"Giesinger","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"S1047951122002839_ref24","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/apa.13866","article-title":"Biventricular function on early echocardiograms in neonatal hypoxic-ischaemic encephalopathy","volume":"106","author":"Aggarwal","year":"2017","journal-title":"Acta 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Giesinger, RE , Bailey, LJ , Deshpande, P and Mcnamara, PJ. Hypoxic-ischemic encephalopathy and therapeutic hypothermia: The hemodynamic perspective. 2017; 180: 22\u201330.e2.","DOI":"10.1016\/j.jpeds.2016.09.009"},{"key":"S1047951122002839_ref8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00246-018-1974-9","article-title":"Immediate postnatal ventricular performance is associated with mortality in hypoplastic left heart syndrome","volume":"40","author":"Altit","year":"2019","journal-title":"Pediatr Cardiol"},{"key":"S1047951122002839_ref1","first-page":"Cd003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"S1047951122002839_ref13","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.echo.2006.09.001","article-title":"Guidelines and standards for performance of a pediatric echocardiogram: a report from the Task Force of the Pediatric Council of the American Society of Echocardiography","volume":"19","author":"Lai","year":"2006","journal-title":"J Am Soc Echocardiogr"},{"key":"S1047951122002839_ref21","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jpeds.2014.01.028","article-title":"Preferential cephalic redistribution of left ventricular cardiac output during therapeutic hypothermia for perinatal hypoxic-ischemic encephalopathy","volume":"164","author":"Hochwald","year":"2014","journal-title":"J Pediatr"},{"key":"S1047951122002839_ref32","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.echo.2012.08.007","article-title":"Variability of global left ventricular deformation analysis using vendor dependent and independent two-dimensional speckle-tracking software in adults","volume":"25","author":"Risum","year":"2012","journal-title":"J Am Soc Echocardiogr"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122002839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:11:06Z","timestamp":1695611466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122002839\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1047951122002839"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122002839","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}