{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:51:41Z","timestamp":1793389901353,"version":"4.5.0"},"reference-count":71,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951122002906_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Long-term physiological dysfunction in coronary\/systemic vasculature may persist in individuals with Kawasaki disease even in the absence of coronary artery abnormalities. We perform a systematic review and meta-analyses of studies assessing long-term vascular function in Kawasaki disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122002906_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed, Embase, and Web of Science databases were searched for relevant literature published till May 2021. Patients with Kawasaki disease were included as cases and healthy age\/sex-matched individuals as controls. Newcastle Ottawa Scale was used to assess the study quality. Outcome measures were differences in markers of vascular function 1 year after diagnosis of Kawasaki disease. Data were analysed using Review Manager software. Comprehensive meta-analysis software was used for meta-regression. To assess the certainty of evidence, GRADE Profiler software was utilised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122002906_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 2280 citations, 49 case-control studies (comprising 2714 cases and 2118 controls) were included for data synthesis. Decreased flow-mediated dilatation [3.83, 95%CI 0.94\u20136.72] and increased pulse-wave velocity [39.34 cm\/sec, 95%CI 20.86\u201357.83], arterial stiffness [0.35, 95%CI 0.11\u20130.59], and common carotid artery intima-media thickness were noted in patients with Kawasaki disease. No significant difference was observed for nitroglycerine-mediated dilatation and endothelial peripheral artery tonometry (endo-PAT). Significant inter-study heterogeneity was observed for flow-mediated dilatation, arterial stiffness, carotid artery intima-media thickness, and endo-PAT. The GRADE evidence was of \u2018very low quality\u2019 for all outcome measures except \u2018moderate quality\u2019 for pulse-wave velocity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951122002906_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Evidence suggests the presence of long-term endothelial dysfunction in patients with Kawasaki disease even in the absence of coronary artery abnormalities. Avoidance of development of other cardiovascular risk factors seems prudent in patients with Kawasaki disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951122002906","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T04:05:18Z","timestamp":1663128318000},"page":"1614-1626","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["Long-term vascular dysfunction in Kawasaki disease: systematic review and meta-analyses"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-7517","authenticated-orcid":false,"given":"Pratap Kumar","family":"Patra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-4267","authenticated-orcid":false,"given":"Aaqib Zaffar","family":"Banday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi Ranjan","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumita","family":"Manohari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur Kumar","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surjit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"S1047951122002906_ref8","unstructured":"8. Sch\u00fcnemann, H , Bro\u017cek, J , Guyatt, G , Oxman, A . GRADE handbook for grading quality of evidence and strength of recommendations. The GRADE Working Group; 2013. Available from: guidelinedevelopment.org\/handbook. Accessed on 03rd Aug 2021."},{"key":"S1047951122002906_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.04.054"},{"key":"S1047951122002906_ref67","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-016-0023-0"},{"key":"S1047951122002906_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130913"},{"key":"S1047951122002906_ref24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.9.2103"},{"key":"S1047951122002906_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13367"},{"key":"S1047951122002906_ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0765-9"},{"key":"S1047951122002906_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307734"},{"key":"S1047951122002906_ref25","unstructured":"25. Duan, C , Du, Z-D , Wang, Y , Jia, L-Q. [Late endothelial function in children with coronary aneurysm due to Kawasaki disease]. Zhongguo Dang Dai Er Ke Za Zhi 2011; 13: 373\u2013376."},{"key":"S1047951122002906_ref7","doi-asserted-by":"crossref","unstructured":"7. Higgins, JPT , Green, S . The Cochrane Collaboration. Cochrane handbook for systematic reviews of interventions Version5.0.0. (2008). www.cochrane-handbook.org.","DOI":"10.1002\/9780470712184"},{"key":"S1047951122002906_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2008.11.006"},{"key":"S1047951122002906_ref5","unstructured":"5. Wells, GA , Shea, B , O\u2019Connell, D , et\u00a0al. Ottawa quality assessment scale: case control studies. 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