{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T19:00:14Z","timestamp":1776625214079,"version":"3.51.2"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951122003432_as1\"><jats:title>Background:<\/jats:title><jats:p>Although previous studies have demonstrated that paediatric pulmonary arterial hypertension remains distinct from that in adults, there are limited studies evaluating a direct comparison between children and adults. The aim of this head-to-head comparison study was to compare the gender, haemodynamic parameters, and prognosis between paediatric and adult pulmonary arterial hypertension.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122003432_as2\"><jats:title>Methods and Results:<\/jats:title><jats:p>We retrospectively assessed the clinical differences in 40 childhood-onset (under 20 years old) patients and 40 adult-onset patients with idiopathic and heritable pulmonary arterial hypertension who were followed up at two centres. There was no female predominance among patients with childhood-onset pulmonary arterial hypertension (child female: 42.5%, adult female: 80%). The percent of New York Heart Association functional class IV in adult-onset pulmonary arterial hypertension tended to be higher than those in childhood-onset pulmonary arterial hypertension (22.5 and 10%, respectively), although children had worse haemodynamic parameters at diagnosis (mean pulmonary artery pressure (children versus adults); median 65 mmHg versus 49 mmHg, p &lt; 0.001). There was no significant difference in the event-free survival rate between the two groups (95% vs. 85%) during the follow-up period (median, 96 months; range, 1\u2013120 months).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951122003432_as3\"><jats:title>Conclusions:<\/jats:title><jats:p>Although paediatric pulmonary arterial hypertension patients had worse haemodynamic parameters at diagnosis than adults, children survived as long as adults with appropriate therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951122003432","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T09:14:15Z","timestamp":1667553255000},"page":"1909-1912","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Clinical differences between children and adults with idiopathic and heritable pulmonary arterial hypertension"],"prefix":"10.1017","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5875-4628","authenticated-orcid":false,"given":"Shinichi","family":"Takatsuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Shimokawahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurika","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"S1047951122003432_ref6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"S1047951122003432_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.42.6.1163"},{"key":"S1047951122003432_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1996-3"},{"key":"S1047951122003432_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61621-8"},{"key":"S1047951122003432_ref5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01120-2020"},{"key":"S1047951122003432_ref3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"S1047951122003432_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2510-4"},{"key":"S1047951122003432_ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0075"},{"key":"S1047951122003432_ref15","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.54.4.428"},{"key":"S1047951122003432_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026591"},{"key":"S1047951122003432_ref11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0058PP"},{"key":"S1047951122003432_ref4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00056110"},{"key":"S1047951122003432_ref10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000012754.72951.3D"},{"key":"S1047951122003432_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0689-7"},{"key":"S1047951122003432_ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0383OC"},{"key":"S1047951122003432_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.10.087"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951122003432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T10:16:38Z","timestamp":1697019398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951122003432\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1047951122003432"],"URL":"https:\/\/doi.org\/10.1017\/s1047951122003432","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. 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